Although T -exchange (T ) NMR phenomena have been known for decades, there has been a resurgence of interest to develop T MRI contrast agents. One indispensable advantage of T MR agents is the possibility of using non-toxic and/or bio-compatible diamagnetic compounds with intermediate exchangeable protons. Herein a library of phenol-based compounds is screened and their T contrast (exchange relaxivity, r ) at 9.4 T determined. The T contrast of phenol protons allows direct detection by MRI at a millimolar concentration level. The effect of chemical modification of the phenol on the T MRI contrast through modulation of exchange rate and chemical shift was also studied and provides a guideline for use of endogenous and exogenous phenols for T MRI contrast. As a proof-of-principle application, phenol T contrast can be used to detect enzyme activity in a tyrosinase-catalyzed catechol oxidation reaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786484 | PMC |
| http://dx.doi.org/10.1002/chem.201705772 | DOI Listing |
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