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Varenicline enhances recognition memory via α7 nicotinic acetylcholine receptors in the medial prefrontal cortex in male mice.
Neuropharmacology
November 2023
Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan. Electronic address:
Previous studies postulated that chronic administration of varenicline, a partial and full agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances recognition memory. However, whether its acute administration is effective, on which brain region(s) it acts, and in what signaling it is involved, remain unknown. To address these issues, we conducted a novel object recognition test using male C57BL/6J mice, focusing on the medial prefrontal cortex (mPFC), a brain region associated with nicotine-induced enhancement of recognition memory.
View Article and Find Full Text PDFVarenicline-induced drug eruption: case and review of the literature.
Dermatol Online J
February 2023
Dermatology Department, Hospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte (CHULN), Lisbon, Portugal.
Cutaneous side-effects of varenicline, a selective partial agonist of the a4B2 nicotinic acetylcholine receptor used to treat smoking addiction, are relatively rare and mainly consist of acute generalized exanthematous pustulosis. We describe an atypical clinical presentation of a varenicline-induced drug eruption, which occurred one day after drug initiation. We report this case since we believe no drug reaction to varenicline has had this clinical presentation or rapidity of onset.
View Article and Find Full Text PDFEvaluation of reproductive and renal toxicity of varenicline in male rats.
Iran J Basic Med Sci
December 2019
Inonu University, School of Medicine, Department of Family Medicine, Malatya, Turkey.
Objectives: Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats.
View Article and Find Full Text PDFVarenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat.
Front Behav Neurosci
July 2019
Psychobiology of Drug Addiction, NeuroCentre Magendie, INSERM U1215, Bordeaux, France.
Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix or Chantix), mainly acting as a partial agonist at the α4β2 nicotinic receptor, is an approved smoking cessation pharmacotherapy, although with efficacy limited to a portion of smokers. Smokers differ in the motives that drive their drug seeking and Varenicline might be more efficient in some groups more than others.
View Article and Find Full Text PDFVarenicline-induced acute generalized exanthematous pustulosis confirmed by patch testing.
Contact Dermatitis
January 2018
Department of Dermatology and Venereology, İstanbul Medical Faculty, İstanbul University, 34093 Çapa-İstanbul, Turkey.
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