AI Article Synopsis
- The study examines the underlying mechanisms and clinical implications of diffuse toxic goiter, specifically looking at proteins related to cell growth and survival in the thyroid.
- Researchers evaluated 24 women who had surgery, measuring the expression of various proteins linked to proliferation and apoptosis using detailed immunohistochemical tests.
- Findings suggest that high levels of the anti-apoptotic protein Bcl-2 and the proliferation marker Ki-67 significantly correlate with the risk of developing postoperative thyrotoxicosis, with high predictive accuracy.
Article Abstract
Unlabelled: The pathogenesis of diffuse toxic goiter has not yet been fully understood. The literature increasing commonly focusses on the issues related to the processes occurring in the thyroid gland itself: proliferation, apoptosis, and angiogenesis.
Aim: to investigate clinical and laboratory parameters, as well as the expression of Ki-67, Bcl-2, Bax, Fas-L, CD34, VEGF, and FGF proteins in various postoperative outcomes of patients operated on for diffuse toxic goiter.
Subjects And Methods: The investigation enrolled 24 women who had undergone surgery using the technique described by E.S. Drachinskaya. Immunohistochemical tests were carried out according to the standard protocol. The expression of Ki-67, Bcl-2, Bax, Fas-L, CD 34, VEGF, angiopoietin, and FGF proteins was determined.
Results: The patients with postoperative thyrotoxicosis were ascertained to have a significantly greater expression of anti-apoptotic protein Bcl-2, proliferation marker Ki-67, vascular factors (FGF, VEGF), and CD 34.
Conclusion: The relative expression area of the anti-apoptotic protein Bcl-2 of more than 2.19 or the proliferation protein Ki-67 of more than 1.059 was found to predict the development of postoperative thyrotoxicosis with an accuracy of higher than 85%.
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| http://dx.doi.org/10.17116/patol20177963-7 | DOI Listing |
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