AI Article Synopsis
- The study aimed to examine the effects of modified Gongjin-dan (WSY-1075) on oxidative stress and detrusor underactivity in a rat model.
- Rats were divided into three groups: a control group, a group with bladder outlet obstruction (BOO-DU), and a group treated with WSY-1075, which was administered before and after the surgery.
- Results indicated that WSY-1075 significantly reduced oxidative stress and helped maintain bladder function compared to the BOO-DU group, suggesting its potential benefits for preventing detrusor underactivity.
Article Abstract
Objective: To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model.
Methods: Rats were randomly allocated to three groups: shamoperated (control), bladder outlet obstruction-induced detrusor underactivity (BOO-DU), and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders.
Results: Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group (P<0.05).
Conclusion: WSY-1075 had beneficial effect on prevention of BOO-DU.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11655-017-2970-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hemostasis is a critical aspect of holmium laser enucleation of the prostate (HoLEP) for benign prostatic hyperplasia (BPH). While HoLEP offers superior outcomes compared to traditional techniques, effective intraoperative and postoperative bleeding control remains a challenge. This report evaluates the feasibility and safety of PuraBond® (3-D Matrix, Ltd.
View Article and Find Full Text PDFMRI-Derived Transition Zone Index Is Highly Predictive of Urodynamic Bladder Outlet Obstruction Prior to Holmium Laser Enucleation of the Prostate.
Neurourol Urodyn
January 2025
Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Introduction And Objective: Urodynamic study (UDS) is required to diagnose bladder outlet obstruction (BOO) during evaluation of benign prostatic hyperplasia (BPH) but is seldom performed due to cost and invasiveness. Therefore, anatomic and clinical parameters to predict BOO have been proposed, including the prostate transition zone index (TZI) which is the ratio of prostate transition zone volume (TZV) to whole gland volume (WGV). Historically computed with ellipsoid volume estimation of prostate WGV and TZV from transrectal ultrasound measurements, controversy exists regarding the utility of TZI to predict likelihood of BOO on UDS and clinical outcomes following BPH surgery.
View Article and Find Full Text PDF"Laser vaporization of the prostate: A comparative study between ejaculatory preserving and non-ejaculatory preserving technique".
Arab J Urol
July 2024
Faculty of Medicine, Urology Department, Ain Shams University, Cairo, Egypt.
Introduction And Objectives: Laser vaporization techniques have emerged as a prominent alternative to transurethral prostate resection in managing benign prostatic obstruction (BPO). This study focuses on assessing the effectiveness of the ejaculatory preserving laser vaporization of the prostate technique compared to the conventional non-ejaculatory approach in managing BPO.
Patients And Methods: Our study was performed between August 2022 and September 2023.
Postvoid Residual Volume Correlates With Bladder Outlet Obstruction and Not With Detrusor Contraction Strength Parameters in Women: A Matched Case-Control Study.
Int Neurourol J
December 2024
Department of Urology, Moinhos de Vento Hospital, Porto Alegre, Brazil.
Purpose: To compare voiding parameters in women with and without increased postvoid residual (PVR) volume, to correlate these parameters with PVR volume and PVR percentage, and to describe their ability to predict an increased PVR volume.
Methods: Retrospective cross-sectional study of urodynamics data prospectively acquired from consecutive symptomatic women over a 5-year period. Patients with spinal cord disorders and with abdominal straining during voiding (abdominal pressure ≥10 cm H2O over baseline at maximum flow rate [Qmax]) were excluded.
Introduction: Solitary fibrous bladder tumors are extremely uncommon, with only a few cases reported. These fibroblastic mesenchymal neoplasms are typically benign, indolent, and slow growing.
Case Presentation: A 44-year-old male patient with obstructive uropathy was referred to our unit for workup.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!