Functional thyroid carcinoma is an unusual cause of thyrotoxicosis. We describe the clinical presentation and treatment of a patient with thyrotoxicosis due to functional thyroid carcinoma and Graves disease, and discuss potential mechanisms causing the thyrotoxicosis. A 79-year-old woman with a remote history of hemithyroidectomy and current hyperthyroidism came to the hospital with upper and lower extremity weakness. Hospital evaluation revealed a suppressed thyroid-stimulating hormone (TSH) level, positive test for thyroid-stimulating immunoglobulins, as well as a thyroid nodule, lung masses, and a 4.4-cm gluteal mass. Fine-needle aspiration of the gluteal mass revealed metastatic differentiated thyroid carcinoma. Even after completion thyroidectomy and excision of her gluteal mass, her hyperthyroid status continued when she was not receiving levothyroxine. A radioactive iodine uptake and scan revealed unusually high lung uptake of 40%, and she was successfully treated with radioactive iodine (RAI) despite complete TSH suppression. The patient developed hypothyroidism 2 months after RAI administration; 6 months after RAI administration, her thyroglobulin (Tg) levels had fallen from a peak of 1976 ng/mL to 1.4 ng/mL. She had no anti-Tg antibodies. Repeated positron emission tomography-computed tomography nearly 1 year after RAI treatment shows substantial regression in the lung nodules, and Tg measured by mass spectroscopy is undetectable. This case demonstrates that thyrotoxicosis in the setting of metastatic thyroid carcinoma may be the result of functional thyroid carcinoma and may be successfully treated with selective surgery and RAI administration.
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http://dx.doi.org/10.1210/js.2017-00296 | DOI Listing |
Int J Gen Med
December 2024
Department of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, South Korea.
Purpose: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Although its mortality rate is low, some patients experience cancer recurrence during follow-up. In this study, we investigated the accuracy of a novel multimodal model by simultaneously analyzing numeric and time-series data to predict recurrence in patients with PTC after thyroidectomy.
View Article and Find Full Text PDFCancer Diagn Progn
January 2025
Department of Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Japan.
Background/aim: The role of lenvatinib as neoadjuvant chemotherapy for patients with advanced thyroid cancer has not been firmly established. In some cases, surgery may be considered when lenvatinib treatment becomes challenging to continue.
Case Report: We present four cases of unresectable thyroid cancer diagnosed histologically as papillary carcinoma.
Eur Arch Otorhinolaryngol
January 2025
Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, China.
Background: Papillary thyroid carcinoma (PTC) is the most common type of endocrine tumor, and its incidence is on the rise. Observational studies have linked cathepsins, an endolysosomal cysteine protein hydrolase, to the malignant progression of several tumors, including PTC. However, the causal relationship between cathepsins and PTC remains unclear.
View Article and Find Full Text PDFThyroid Res
January 2025
The First Affiliated Hospital, Shihezi University, Shihezi, China.
Background: This study aimed to evaluate the efficacy and safety of thermal ablation in the treatment of patients with Bethesda IV thyroid nodules (follicular neoplasms) by analyzing large-scale data on various outcomes.
Materials And Methods: Literature searches were conducted in PUBMED, EMBASE, Web of Science, and the Cochrane Library for studies on the use of thermal ablation in patients with Bethesda IV thyroid nodules published from March 1, 2014, to March 1, 2024. Data on volume change at 12 months; the volume reduction rate (VRR) at 1, 3, 6, and 12 months; the complete disappearance rate (CDR); and the complication rate were evaluated.
Acad Radiol
January 2025
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (J-W.F., H.L.); Zhejiang Engineering Research Center of Cognitive Healthcare, Sir Run Run Shaw Hospital,School of Medicine, Zhejiang University, Hangzhou, China (H.L.); College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China (H.L.). Electronic address:
Rationale And Objectives: Papillary thyroid carcinoma (PTC) often metastasizes to lateral cervical lymph nodes, especially in level II. This study aims to develop predictive models to identify level II lymph node metastasis (LNM), guiding selective neck dissection (SND) to minimize unnecessary surgery and morbidity in low-risk patients.
Methods: A retrospective cohort of 313 PTC patients who underwent modified radical neck dissection (MRND) between October 2020 and January 2023 was analyzed.
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