Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8 T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory, follicular CXCR5, and HIV-specific CD8 T cells from LNs do not manifest the properties of cytolytic CD8 T cells. While the frequency of follicular CXCR5 CD8 T cells was strongly inversely associated with peripheral viremia, this association was not dependent on cytolytic CXCR5 CD8 T cells. Moreover, the poor cytolytic activity of LN CD8 T cells was linked to a compartmentalized dissociation between effector programming and the transcription factor T-bet. In line with this, activation of LN CD8 T cells only partially induced the acquisition of cytolytic functions relative to peripheral blood CD8 T cells. These results suggest that a state of immune privilege against CD8 T cell-mediated cytolysis exists in lymphoid tissue, potentially facilitating the persistence of HIV.
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| http://dx.doi.org/10.1016/j.celrep.2017.11.075 | DOI Listing |
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