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Nuclear podosomes regulates cellular migration in Tau and Alzheimer's disease.
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Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences Hospital (NIMHANS), Institute of National Importance, Bangalore, Karnataka, India. Electronic address:
The neuronal cytoskeleton has remained a less explored area of research in establishing neuroprotection. HDAC6 has been studied with respect to many neurodegenerative diseases, especially AD. It exhibits the ability to interact with various cytoskeletal proteins and to promote migration in cells.
View Article and Find Full Text PDFNOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion.
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Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, 5090000, Valdivia, Chile.
NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at the cellular surface. In cancer, these highly reactive molecules primarily originate in mitochondria and via NOX, playing a crucial role in regulating fundamental cellular processes such as cell survival, angiogenesis, migration, invasion, and metastasis. The NOX protein family comprises seven members (NOX1-5 and DUOX1-2), each sharing a catalytic domain and an intracellular dehydrogenase site.
View Article and Find Full Text PDFAutophagy Regulator Rufy 4 Promotes Osteoclastic Bone Resorption by Orchestrating Cytoskeletal Organization via Its RUN Domain.
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Department of Dental Pharmacology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
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View Article and Find Full Text PDFYAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer.
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View Article and Find Full Text PDFBLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration.
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Department of Infection and Immunity, Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
Article Synopsis
- B cell linker protein (BLNK) is essential for signaling in B cells, but its role in macrophages during C-type lectin receptor (CLR) signaling is not well understood.
- The study reveals that CLRs activate BLNK, which hinders macrophage migration by disrupting podosome ring formation in response to fungal components.
- BLNK deficiency leads to increased macrophage migration and enhanced resistance to fungal infections by promoting the recruitment of specific macrophages to affected tissues.
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