AI Article Synopsis
- Studies have found that children with ADHD show reduced frontal and central event-related potentials (ERPs) compared to typically developing children when processing Cue-Go/NoGo tasks.
- This study analyzed EEG dynamics related to these ERPs in 14 children, revealing that those with ADHD had significant differences in brain wave patterns, specifically lower theta-alpha inter-trial coherence and power across various stimulus conditions.
- The results indicate a possible impairment in ADHD children's ability to maintain brain oscillation phases during stimulus processing, highlighting a potential target for therapy and monitoring of treatment effects.
Article Abstract
Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD.
Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years.
Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli.
Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742770 | PMC |
| http://dx.doi.org/10.3390/brainsci7120167 | DOI Listing |
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