Troponin is considered to be the gold standard biomarker for ruling out MI. There has been a drive to improve the diagnostic speed, and as such the high sensitivity cardiac troponin (hs-cTn) assays have been introduced into clinical practice and are now part of international guidelines. Their novel value in clinical practice more generally is becoming apparent. Areas covered: In this review we will evaluate the evidence for the use of hs-cTn assays in clinical practice, the issues with the assay and how the hs-cTn can be utilized in the future as a biomarker of cardiovascular risk. Expert commentary: The use of the hs-cTn assays as a 'rule out' test for MI is compelling, as a 'rule in' there are significant issues relating the specificity of the assay for MI. The future of the assay may lie in population screening and risk modeling.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14779072.2018.1419063 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transitioning to high-sensitivity troponin: 1-year mortality outcomes in patients with suspected acute coronary syndrome presenting to emergency departments.
Heart
January 2025
Cardiovascular Epidemiology Research Centre, School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
Background: Switching from a conventional to a high-sensitivity cardiac troponin (hs-cTn) assay enables detection of smaller amounts of myocardial damage, but the clinical benefit is unclear. We investigated whether switching to a hs-cTnI assay with a sex-specific 99th centile diagnostic threshold was associated with lower 1-year death or new myocardial infarction (MI) in patients with suspected acute coronary syndrome (ACS).
Methods: This pre-post study included nine tertiary hospitals in Australia.
Elevated Plasma Nitrate Levels in Patients with Acute Coronary Syndrome.
Am J Cardiol
January 2025
Department of Cardiology, Apollo Institute of Medical Science and Research, Apollo Health City, Hyderabad, Telangana, India.
Acute coronary syndrome (ACS) encompasses a spectrum of coronary artery diseases, including unstable angina, non-ST segment elevation myocardial infarction, and ST-segment elevation MI. At present, ACS is a major cause of mortality and morbidity in the community. The diagnosis of ACS is of critical importance for guiding appropriate therapeutic strategies, although this can be onerous if the standard presenting manifestations are lacking.
View Article and Find Full Text PDFHow Close Are We to Patient-Side Troponin Testing?
J Clin Med
December 2024
BHF Centre of Research Excellence, The Rayne Institute, King's College London, 4th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Laboratory-based high-sensitivity cardiac troponin testing has been the pillar for emergency stratification of suspected acute coronary syndrome for well over a decade. Point-of-care troponin assays achieving the requisite analytical sensitivity have recently been developed and could accelerate such assessment. This review summarises the latest assays and describes their potential diverse clinical utility in the emergency department, community healthcare, pre-hospital, and other hospital settings.
View Article and Find Full Text PDFResearch on the mechanism of the anti-myocardial infarction effect of the Qiliqiangxin capsule on heart failure rats via nontargeted metabolomics and lipidomics.
BMC Cardiovasc Disord
December 2024
Jiangxi University of Chinese Medicine, Jiangxi, China.
Article Synopsis
- The Qi Li Qiang Xin (QLQX) capsule shows promise in treating chronic heart failure, with the study aiming to uncover its mechanisms through metabolomics and lipidomics analysis.
- A rat model of heart failure was used to assess the effects of QLQX compared to a control group (SHAM), a myocardial infarction (MI) group, and a valsartan group, with various metrics for cardiac function and morphology being measured.
- Results indicated that QLQX improved heart function and reduced heart failure markers, while metabolomics analysis identified 17 significant plasma metabolites that were beneficially affected by QLQX treatment, indicating its role in biochemical pathways associated with heart health.
Diagnostic and Prognostic Performance of High-Sensitivity Cardiac Troponin T vs I.
J Am Coll Cardiol
November 2024
Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Rome, Italy. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!