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Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.
Gastric Cancer
January 2025
Department of Medical Oncology, Hospital Clinico Universitario, INCLIVA, Biomedical Research Institute, University of Valencia, Avenida Menendez Pelayo nro 4 accesorio, Valencia, Spain.
Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.
Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.
Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.
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January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
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Department of Medicine, Nephrology Division, University of Verona, Verona, Italy.
Introduction: Pain is one of the most frequently reported symptoms in hemodialyzed (HD) patients, with prevalence rates between 33% and 82%. Risk factors for chronic pain in HD patients are older age, long-lasting dialysis history, several concomitant diseases, malnutrition, and others. However, chronic pain assessment in HD patients is rarely performed by specialists in pain medicine, with relevant consequences in terms of diagnostic and treatment accuracy.
View Article and Find Full Text PDFContamination assessment and source identification of metals and metalloids in submicron road dust (PM) in Moscow Megacity.
Environ Sci Pollut Res Int
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Faculty of Geography, Lomonosov Moscow State University, 119991, Moscow, Russia.
The content of 39 metals and metalloids (MMs) in submicron road dust (PM fraction) was studied in the traffic zone, residential courtyards with parking lots, and on pedestrian roads in parks in Moscow. The geochemical profiles of PM vary slightly between different types of roads and courtyards but differ significantly from those in parks. In Moscow, compared to other cities worldwide, submicron road dust contains less As, Sb, Mo, Cr, Cd, Sn, Tl, Ca, Rb, La, Y, U, but more Cu, Zn, Co, Fe, Mn, Ti, Zr, Al, V.
View Article and Find Full Text PDFQuantitative risk assessment of rainstorm-induced flood disaster in Piedmont plain of Pakistan.
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State Key Laboratory of Geohazard Prevention and GeoEnvironment Protection, Chengdu University of Technology, Chengdu, 610059, Sichuan, China.
Pakistan's geographic location makes it an important land hub between Central Asia, Middle East-North Africa, and China. However, the railways, roads, farmland, riverways, and residential quarters in the Piedmont plains of Baluchistan province in northwestern Pakistan are under serious threat of flooding in the summer of 2022. The urgency and severity of climate change's impact on humanity are underscored by the significant threats posed to human life and property in Piedmont Plains environments through extreme flood events, which has garnered widespread concerns.
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