AI Article Synopsis
- The study investigates how different patterns of ultraviolet radiation (UVR) exposure affect the development of squamous cell carcinoma in hairless pigmented mice.
- In the dose-delivery study, changing the fractionation of UVR doses didn't impact the time it took for tumors to develop, while the dose-response study showed that higher UVR doses led to quicker tumor formation.
- Reducing the total weekly UVR dose from 12 to 6 SED decreased the overall UVR dose required for tumor development by 40%, suggesting that lower doses may prolong tumor development time but require less cumulative radiation for tumors to appear.
Article Abstract
Cumulative lifetime ultraviolet radiation (UVR) is an important factor in the development of squamous cell carcinoma. This study examines the impact of UVR exposure pattern on tumor development. Hairless C3.Cg/TifBomTac immunocompetent pigmented mice ( = 351) were irradiated with 12 standard erythema doses (SED)/week, given as 2 SED ×6, 3 SED ×4, 4 SED ×3, or 6 SED ×2 (dose-delivery study) or 0, 0.6, 1.2, 2, 3 or 4 SED ×3/week (dose-response study). All mice were irradiated until development of 3 tumors of 4 mm each. Pigmentation was measured once monthly. In the dose-delivery study, the median time until tumor development was independent of dose fractions. In the dose-response study, higher UVR doses resulted in faster tumor appearance. When the weekly UVR dose was decreased from 12 to 6 SED, the cumulative UVR dose needed for tumor development was reduced by 40%. In conclusion, delivery schedules of a fixed weekly UVR dose did not affect tumor development. When using different weekly UVR doses, longer time to tumor development was observed using lower UVR doses. Lower weekly UVR doses however resulted in lower cumulative UVR doses to induce tumors in hairless pigmented mice.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751339 | PMC |
| http://dx.doi.org/10.3390/ijms18122738 | DOI Listing |
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