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The Evolution of Widespread Recombination Suppression on the Dwarf Hamster (Phodopus) X Chromosome.
Genome Biol Evol
May 2022
Division of Biological Sciences, The University of Montana, Missoula, Montana, 59812, USA.
The X chromosome of therian mammals shows strong conservation among distantly related species, limiting insights into the distinct selective processes that have shaped sex chromosome evolution. We constructed a chromosome-scale de novo genome assembly for the Siberian dwarf hamster (Phodopus sungorus), a species reported to show extensive recombination suppression across an entire arm of the X chromosome. Combining a physical genome assembly based on shotgun and long-range proximity ligation sequencing with a dense genetic map, we detected widespread suppression of female recombination across ∼65% of the Phodopus X chromosome.
View Article and Find Full Text PDFOnychodystrophy as the Presenting Sign of Steal Syndrome.
Skin Appendage Disord
August 2021
Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA.
A man in his 70s presented to the dermatology nail clinic with a 1-month history of worsening onychodystrophy, leukonychia, and pain in his left fifth finger. Physical examination revealed a cool hand and absent radial pulse. Ischemia was suspected, and the patient was sent to the emergency department where the diagnosis of steal syndrome was made and his previously required arteriovenous fistula was ligated.
View Article and Find Full Text PDFThe purpose of this research was to explore the impact of Jin Shin Jyutsu (JSJ) Self-Help on personal stress and the caring efficacy of nurses. A randomized, controlled comparison study, with crossover design was conducted. Stress and caring efficacy were measured via surveys at baseline, posteducation, and again 30 to 40 days after completion of the JSJ educational intervention.
View Article and Find Full Text PDFSpectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.
Cancer
July 2020
Division of Hematology-Oncology, Department of Internal Medicine, University of California Davis Comprehensive Cancer Center, Sacramento, California.
Background: Circulating cell-free tumor DNA (ctDNA)-based mutation profiling, if sufficiently sensitive and comprehensive, can efficiently identify genomic targets in advanced lung adenocarcinoma. Therefore, the authors investigated the accuracy and clinical utility of a commercially available digital next-generation sequencing platform in a large series of patients with non-small cell lung cancer (NSCLC).
Methods: Plasma-based comprehensive genomic profiling results from 8388 consecutively tested patients with advanced NSCLC were analyzed.
Polycyclic Dermatitis: An Unusual Presentation of Allergic Contact Dermatitis to Rubber Accelerators.
Dermatitis
December 2020
From the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.
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