Marion County Public Health Department (MCPHD) in Indianapolis, Indiana, was awarded funding in 2009 from the U.S. Department of Housing and Urban Development through the Healthy Homes Demonstration Grant Program as a part of the American Recovery and Reinvestment Act. This funding is currently supporting activities addressing health and safety hazards in homes of low- and very low-income residents living in an urban community within Marion County with an extensive history of heavy industry and lead smelting. One portion of this grant is being used to fund IRB-approved research conducted by MCPHD for the period of the grant. Development and implementation of this study has provided both unique challenges and positive opportunities for study participants, MCPHD, and community stakeholders. The following commentary provides insight into the benefits and rewards of implementing a successful study process, as well as challenges in implementing a community-based research study for the first time in a preexisting Healthy Homes Demonstration Grant Program health department.

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