AI Article Synopsis
- The review focuses on the latest developments in ALK inhibitors (ALK-TKIs) for treating ALK-positive non-small cell lung cancer (NSCLC).
- Since the approval of crizotinib in 2011, three second-generation ALK-TKIs (ceritinib, alectinib, brigatinib) have been introduced, along with promising options for overcoming treatment resistance.
- The summary includes updates from recent clinical trials, particularly phase III studies on ceritinib and alectinib, and addresses the challenges of brain metastases and resistance to ALK-TKIs.
Article Abstract
Purpose Of Review: The review will highlight recent advances in development of ALK-TKIs and management of patients with ALK-positive nonsmall cell lung cancer.
Recent Findings: There has been rapid progress in the use of targeted therapies for ALK-positive NSCLC. Since the discovery, development and approval of crizotinib in 2011, three second-generation ALK-TKIs, ceritinib, alectinib and brigatinib have been approved by the FDA. A range of newer generation ALK inhibitors with improved potency against ALK and against mutations that confer resistance to crizotinib are in clinical development.
Summary: Our review will discuss the recent phase III data with ceritinib and alectinib as well as clinical trials with other ALK inhibitors. We will also address two important issues in the management of ALK-positive NSCLC, prevention and treatment of brain metastases and management of emergent ALK-TKI resistance mechanisms.
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| http://dx.doi.org/10.1097/CCO.0000000000000431 | DOI Listing |
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