AI Article Synopsis
- Researchers developed a method for regioselective halogenation of arenes and heterocycles using N-halosuccinimides in fluorinated alcohols under mild conditions.
- The process yields a diverse range of halogenated arenes with good efficiency and high regional selectivity.
- The method also allows for one-pot sequential reactions, facilitating both halogenation and halogenation-Suzuki cross-coupling processes.
Article Abstract
Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.
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| http://dx.doi.org/10.1021/acs.joc.7b02920 | DOI Listing |
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