Individual-difference research on reading comprehension is challenging because reader characteristics are as correlated with each other as they are with comprehension. This study was conducted to determine which abilities are central to explaining comprehension and which are secondary to other abilities. A battery of psycholinguistic and cognitive tests was administered to community college and university students. Seven constructs were identified: word decoding, working-memory capacity (WMC), general reasoning, verbal fluency, perceptual speed, inhibition, and language experience. Only general reasoning and language experience had direct effects; these two variables accounted for as much variance in comprehension as did the complete set. Direct effects of WMC and decoding were found only when general reasoning and language experience were deleted from the models. The authors question the need to include WMC in our theories of variability in adult reading comprehension and highlight the need to understand precisely how vocabulary facilitates comprehension.
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http://dx.doi.org/10.1016/j.jml.2017.07.008 | DOI Listing |
Interact J Med Res
January 2025
Medical Directorate, Lausanne University Hospital, Lausanne, Switzerland.
Large language models (LLMs) are artificial intelligence tools that have the prospect of profoundly changing how we practice all aspects of medicine. Considering the incredible potential of LLMs in medicine and the interest of many health care stakeholders for implementation into routine practice, it is therefore essential that clinicians be aware of the basic risks associated with the use of these models. Namely, a significant risk associated with the use of LLMs is their potential to create hallucinations.
View Article and Find Full Text PDFChin Med
January 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China.
Background: Cutaneous hypertrophic scar is a fibro-proliferative hard-curing disease. Recent studies have proved that antagonists of angiotensin II type 1 receptor (ATR) and agonists of type 2 receptor (ATR) were able to relieve hypertrophic scar. Therefore, establishing new methods to pursue dual-target lead compounds from Chinese herbs is in much demand for treating scar.
View Article and Find Full Text PDFIn cybersecurity, anomaly detection in tabular data is essential for ensuring information security. While traditional machine learning and deep learning methods have shown some success, they continue to face significant challenges in terms of generalization. To address these limitations, this paper presents an innovative method for tabular data anomaly detection based on large language models, called "Tabular Anomaly Detection via Guided Prompts" (TAD-GP).
View Article and Find Full Text PDFChembiochem
January 2025
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Biosynthesis of Natural Products, 1# Xian Nong Tan Street, 100050, Beijing, CHINA.
There is no doubt that breakthroughs in the enzyme-mediated formation of the oxetane ring in paclitaxel biosynthesis constitute significant milestones in the biosynthesis of complex natural products. In this review, we summarize the understanding of the biosynthesis of the oxetane ring of paclitaxel from different viewpoints. Generally, it covers five aspects, (1) a different understanding of the mechanistic formation of the oxetane ring on the basis of sound chemical reasoning, (2) a reasonable speculation of the biosynthetic pathways and suitable surrogate substrates for oxetane ring formation based on the natural and chemical logical analysis, (3) Taxus genome-enabled enzymes identification, (4) the discovery of different enzymes that mediate oxetane ring formation, and (5) a mechanistic investigation involving the use of isotopic labelling experiments and quantum chemical calculations.
View Article and Find Full Text PDFEmerging evidence suggests that inhibitory control (IC) plays a pivotal role in science and maths counterintuitive reasoning by suppressing incorrect intuitive concepts, allowing correct counterintuitive concepts to come to mind. Neuroimaging studies have shown greater activation in the ventrolateral and dorsolateral pFCs when adults and adolescents reason about counterintuitive concepts, which has been interpreted as reflecting IC recruitment. However, the extent to which neural systems underlying IC support science and maths reasoning remains unexplored in children.
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