Introduction: The aim of this study was to evaluate some of the physicochemical properties of a new root canal sealer.
Methods: The sealers tested were Sealer Plus compared with AH Plus. For the radiopacity, flow, solubility, and fabrication of test specimens relative to setting times, the American National Standards Institute/American Dental Association No. 57 (2000) and International Organization for Standardization 6876 (2012) specifications were followed. To measure the initial and final setting times, the ASTM C266/2008 standard was used. pH was evaluated in the time intervals of 3, 24, 72, and 168 hours. Statistical tests were applied to the results obtained at a level of significance of 5%.
Results: The results demonstrated that the Sealer Plus sealer showed a lower radiopacity value than AH Plus sealer (P < .05); however, this was higher than the minimum value recommended by the specifications (ie, 3 mm Al). Relative to flow, the value for Sealer Plus was 19.19 mm and for AH Plus, 19.81 mm (P > .05). Sealer Plus presented initial and final setting times of 138 minutes and 210 minutes, respectively, whereas the values for AH Plus were 437 minutes and 849 minutes, respectively (P < .05). Relative to solubility, Sealer Plus presented 0.21% and AH Plus, 0.27% (P > .05). None of the sealers showed a significant increase in pH (P > .05).
Conclusions: Sealer Plus sealer presented physicochemical properties in accordance with American National Standards Institute/American Dental Association (2000) No. 57 and International Organization for Standardization 6876 (2012) specifications.
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http://dx.doi.org/10.1016/j.joen.2017.09.017 | DOI Listing |
Cell Mol Biol (Noisy-le-grand)
January 2025
College of Life Sciences, Liaoning Normal University, Dalian 116000, Liaoning Province, China.
Liaoning cashmere goat is an outstanding breed in China primarily for cashmere production, with strict controls against genetic outflow. Melatonin(MT) is a key factor affecting cashmere growth, and preliminary transcriptome sequencing indicated that melatonin upregulates the expression of the PIP5K1A gene in skin fibroblasts. To predict the physicochemical properties of PIP5K1A in Liaoning cashmere goats, ascertain the tissue localization of PIP5K1A in their skin, and explore the role and mechanism of PIP5K1A in the proliferation of skin fibroblasts.
View Article and Find Full Text PDFSci Rep
January 2025
Chemistry Department, School of Advanced Sciences, Vellore Institute of Technology-Chennai campus, Chennai, 600127, India.
Nickel complexes are a potential candidate for antibacterial and antifungal activity. A new Ni (II) complex, bis(2-methoxy-6-{[(2-methylpropyl)imino]methyl}phenolato)nickel (II) (2), was synthesised by reacting, bis(3-methoxy-salicylaldehyde)nickel (II) (1) with isobutylamine. It was characterised by single crystal X-ray diffraction (ScXRD), UV-Vis, NMR, IR, mass spectrometry, and thermogravimetry (TG) to study its structure and physico-chemical properties.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Mathematical Sciences, Faculty of Science, Somali National University, Mogadishu Campus, Mogadishu, Somalia.
In recent years, machine learning has gained substantial attention for its ability to predict complex chemical and biological properties, including those of pharmaceutical compounds. This study proposes a machine learning-based quantitative structure-property relationship (QSPR) model for predicting the physicochemical properties of anti-arrhythmia drugs using topological descriptors. Anti-arrhythmic drug development is challenging due to the complex relationship between chemical structure and drug efficacy.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Bioengineering, School of Engineering, The University of Tokyo; Institute of Medical Science, The University of Tokyo; Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo; Medical Device Development and Regulation Research Center, School of Engineering, The University of Tokyo, Japan. Electronic address:
Post-translational modification of proteins is a crucial biological reaction that regulates protein functions by altering molecular properties. The specific detection of such modifications in proteins has made significant contributions to molecular biology research and holds potential for future drug development applications. In HIV research, for example, tyrosine sulfation at the N-terminus of C-C chemokine receptor type 5 (CCR5) is considered to significantly enhance HIV infection efficiency.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China.
Cartilage repair remains a formidable challenge because of its limited regenerative capacity. Construction of a biomimetic hydrogel matrix that can induce cell aggregation is a promising therapeutic option. Cell aggregates are more beneficial than dissociated cells for improving survival and chondrogenic differentiation, thereby facilitating cartilage repair.
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