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Primary Remitting Seronegative Symmetrical Synovitis With Pitting Oedema: A Case Report.
Cureus
January 2025
Internal Medicine, Hospital Infante D. Pedro, Aveiro, PRT.
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome is a rare disease that typically presents in older men and is characterised by bilateral and symmetrical peripheral arthritis, pitting oedema in the dorsal hands and feet, and seronegativity for rheumatoid factor. A notable feature of this syndrome is its excellent response to systemic corticosteroid therapy. This article presents a case of a 75-year-old White male patient recently diagnosed with bilateral carpal tunnel syndrome.
View Article and Find Full Text PDFRemitting Seronegative Symmetrical Synovitis With Pitting Edema Syndrome With Fever as the First Clinical Manifestation:Report of One Case.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2024
Department of Respiratory Medicine, Foshan Hospital of Traditional Chinese Medicine,Foshan,Guangdong 528000,China.
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare seronegative synovial inflammatory disease in which fever is a rare symptom.There are few case reports of RS3PE syndrome with fever as the first clinical manifestation in China.In this paper,we report a case of RS3PE syndrome with fever as the first symptom and diagnosed by systematic fever investigation.
View Article and Find Full Text PDFRemitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a type of seronegative arthritis characterized by a favorable prognosis (Remitting), absence of rheumatoid factor (Seronegative), symmetry (Symmetrical), and synovitis with pitting edema on the backs of the hands and feet. The cause of RS3PE syndrome remains unknown, but involvement of the immune system is suspected, and steroids are highly effective. Here, we present a case of an 86-year-old woman with severe anemia and bilateral lower limb edema accompanied by chronic eczema, considered to be caused by RS3PE syndrome.
View Article and Find Full Text PDFCommon Comorbidities in Patients with Remitting Seronegative and Symmetrical Synovitis with Pitting Edema (RS3PE).
South Med J
May 2024
Arthritis Associates of Kingsport, Kingsport, Tennessee.
Objectives: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is considered a rare inflammatory rheumatologic disorder that is seen primarily in older adult men. Patients present with arthralgias of large joints accompanied by painful pitting edema of the hands and feet. Few studies have reported the prevalence of metabolic syndromes, including diabetes mellitus and hyperlipidemia in these patients.
View Article and Find Full Text PDFAnti-interleukin-6 receptor antibody for the treatment of remitting seronegative symmetrical synovitis with pitting oedema: a new outlook?
BMJ Case Rep
March 2024
Internal Medicine, Hospital Pedro Hispano, Matosinhos, Portugal.
We present the case of an elderly man with a small-joint polyarthritis, accompanied by pitting oedema, involving hands and feet, raising clinical suspicion of remitting seronegative symmetrical synovitis with pitting oedema (RS3PE). Treatment with corticosteroids was initiated with significant improvement, but unacceptable iatrogeny ensued, and tapering was not possible without disease flare-up. A trial of tocilizumab allowed disease activity control, slow weaning of corticosteroids and, ultimately, its suspension.
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