AI Article Synopsis
- Depression is the top cause of disability globally, with about one-third of patients not responding to traditional antidepressants, prompting the exploration of new treatments like fish oil.
- Fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), shows promise in improving depression management due to its anti-inflammatory properties and effects on cell membranes.
- The review will look at clinical trials on fish oil for depression treatment and the cellular mechanisms, particularly focusing on lipid rafts and G-proteins that might play a role in its antidepressant effects.
Article Abstract
Depression is the leading cause of disability worldwide, and even though many forms of therapy exist, about one third of patients treated with conventional antidepressants do not experience a response. For these reasons, new approaches to treat depression, including fish oil, are being investigated. Fish oil is known to have many beneficial side effects, and clinical trials demonstrate that supplementation with fish oil is beneficial in the management of depression. Fish oil contains omega-3 polyunsaturated fatty acids (PUFA), and there are several mechanisms by which PUFAs are thought to induce an antidepressant effect, including anti-inflammatory action and direct effects on membrane properties. This review will analyze and evaluate the clinical trials surrounding fish oil use in the treatment of depression, and will also review the likely sites of action of PUFAs at the cell membrane with special attention being placed on lipid rafts and G-proteins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087692 | PMC |
| http://dx.doi.org/10.3233/JIN-170072 | DOI Listing |
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