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Integration of Optical Coherence Tomography Images and Real-Life Clinical Data for Deep Learning Modeling: A Unified Approach in Prognostication of Diabetic Macular Edema.
J Biophotonics
December 2024
Medical Faculty, Ophthalmology Department, University of Health Sciences, Istanbul, Türkiye.
The primary ocular effect of diabetes is diabetic retinopathy (DR), which is associated with diabetic microangiopathy. Diabetic macular edema (DME) can cause vision loss for people with DR. For this reason, deciding on the appropriate treatment and follow-up has a critical role in terms of curing the disease.
View Article and Find Full Text PDFFirst case report of septic arthritis associated with an indwelling device.
Future Microbiol
December 2024
Department of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
usually presents with erythrasma, a macular rash, but rarely it can cause extracutaneous infections such as endocarditis, peritonitis, pyelonephritis, and catheter-related bloodstream infections. Here, we present the first case of septic arthritis caused by and a literature review of invasive infections. The diagnosis was confirmed by the patient's clinical findings and microbiological examination of the joint fluid.
View Article and Find Full Text PDFRFMiD: Retinal Image Analysis for multi-Disease Detection challenge.
Med Image Anal
January 2025
ImViA EA 7535/ IFTIM, Université de Bourgogne, 21078 Dijon, France.
Article Synopsis
- Large datasets of fundus images for eye diseases have been collected to train deep learning models for diagnosing common conditions like diabetic retinopathy, but many systems overlook rare, sight-threatening diseases.
- A grand challenge called "Retinal Image Analysis for multi-Disease Detection" was held at the IEEE International Symposium on Biomedical Imaging to enhance automatic detection for both common and rare eye diseases, using a new dataset called RFMiD.
- The challenge attracted significant interest, with 74 submissions, and the best solutions combined techniques like data-preprocessing, augmentation, and model ensembling to improve detection capabilities across a wider range of ocular diseases.
How Advanced are Nanocarriers for Effective Subretinal Injection?
Int J Nanomedicine
September 2024
Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Subretinal injection (SR injection) is a commonly used method of ocular drug delivery and has been mainly applied for the treatment of neovascular age-associated macular degeneration (nAMD) and sub-macular hemorrhage (SMH) caused by nAMD, as well as various types of hereditary retinopathies (IRD) such as Stargardt's disease (STGD), retinitis pigmentosa (RP), and a series of fundus diseases such as Leber's congenital dark haze (LCA), choroidal defects, etc. The commonly used carriers of SR injection are mainly divided into viral and non-viral vectors. Leber's congenital amaurosis (LCA), choroidal agenesis, and a series of other fundus diseases are also commonly treated using SR injection.
View Article and Find Full Text PDFEconomic Assessment in Resource-Constrained Systems: Individual-Level Simulation Model in Wet Age-Related Macular Degeneration and Diabetic Macular Oedema.
Ophthalmol Ther
October 2024
F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Introduction: Cost-effectiveness analyses typically ignore healthcare system resource constraints. Ophthalmology is affected by resource constraints because of increasing disease prevalence and the use of resource-intensive treatments. This study evaluated the impact of resource constraints on the cost-effectiveness of faricimab 6 mg, compared with aflibercept 2 mg and ranibizumab biosimilar 0.
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