Unlabelled: Low back pain (LBP) and lower-extremity injuries (LEI) are primary reasons for lost duty days and disability among military populations.
Purpose: This study examined acute LEI as a risk factor for developing LBP and examined the time to incident LBP between individuals with and without a history of LEI.
Methods: This retrospective cohort study examined U.S. Army medical and personnel data from the Total Army Injury and Health Outcomes Database for the years 2007 to 2011. Andersen-Gill Cox regression methods were used to examine the change in LEI status over time and changes in demographic covariates. Adjusted hazard ratios (HR) for LBP after LEI were calculated from the Cox regression model for each calendar year. An accelerated failure time (AFT) model was used to describe time to LBP, and mean time to event and adjusted time ratios (TR) after LEI were calculated from the AFT model for each year. Overall HR and TR for LBP after LEI were calculated over the five calendar years using variance-based weighted averages.
Results: Each yearly analysis included an average of 213,307 soldiers; on average for each year 8.44% of soldiers developed LBP and 11.54% had previous LEI. The pooled TR showed soldiers with a LEI had a 10% decrease in mean survival times to LBP compared to those without a LEI (TR, 0.901; 95% confidence interval, 0.897-0.905). The weighted average HR showed that soldiers with a LEI had 1.7 times the hazard of LBP compared with those without LEI (HR, 1.70; 95% confidence interval, 1.66-1.74).
Conclusions: These findings suggest that a potential second-order effect of LEI is an increased short-term risk for developing LBP, which should be considered during rehabilitation planning.
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http://dx.doi.org/10.1249/MSS.0000000000001523 | DOI Listing |
BMC Pulm Med
January 2025
Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Research indicates that obesity can worsen the clinical manifestations of chronic obstructive pulmonary disease (COPD). Timely detection of COPD has the potential to enhance treatment results. This study seeks to investigate the association between a new metabolic indicator, the lipid accumulation product (LAP), and the risk of developing COPD.
View Article and Find Full Text PDFSci Rep
January 2025
Reproductive Biology Laboratory, Centre for Reproductive Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105AZ, The Netherlands.
Radiation therapy is a common treatment modality for lung cancer, and resistance to radiation can significantly affect treatment outcomes. We recently described that lung cancer cells that express more germ cell cancer genes (GC genes, genes that are usually restricted to the germ line) can repair DNA double-strand breaks more rapidly, show higher rates of proliferation and are more resistant to ionizing radiation than cells that express fewer GC genes. The gene encoding TRIP13 appeared to play a large role in this malignant phenotype.
View Article and Find Full Text PDFLupus Sci Med
January 2025
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Objective: Both belimumab and telitacicept are recognised blockers for B lymphocyte activation, both of which have been approved as add-on therapies for SLE in China. The aim of this study is to compare the efficacy of rituximab (RTX) followed by belimumab or telitacicept in a real-world cohort.
Methods: A total of 49 refractory lupus nephritis patients were enrolled from four independent centres, subsequently categorised into two treatment groups: belimumab group (n=35) and telitacicept group (n=14) based on their treatment following RTX.
BMC Nurs
January 2025
Yichang Hubo Medical Research Institute, Yichang City, Hubei Province, 443003, China.
Aim: This study aimed to assess the relationship between compulsory citizenship behavior and nurses' silence.
Methods: A descriptive cross-sectional online study was conducted in October 2023, targeting 402 nurses working in Yichang Central People's Hospital, Hubei Province, China. Data were collected through a structured questionnaire comprising demographic details, the Compulsory Citizenship Behavior Scale, and the Nurses' Silence Scale.
ACS Appl Mater Interfaces
January 2025
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
The ongoing soft actuation has accentuated the demand for dielectric elastomers (DEs) capable of large deformation to replace the traditional rigid mechanical apparatus. However, the low actuation strain of DEs considerably limits their practical applications. This work developed high-performance polyurethane-urea (PUU) elastomers featuring large actuation strains utilizing an approach of kinetic control over the microphase separation structure during the fabrication process.
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