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Asymptomatic multifocal avascular necrosis, a commonly overlooked finding in patients with systemic lupus erythematosus.
BMC Rheumatol
December 2024
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Background: In patients with Systemic lupus erythematosus (SLE), osteonecrosis of various joints is a debilitating complication associated with the disease and its treatment, in which a considerable proportion of osteonecrosis may be asymptomatic. Recognizing the crucial role of early and timely detection, as well as appropriate management of asymptomatic osteonecrosis, in preventing joint destruction, we conducted a study to evaluate the prevalence of asymptomatic osteonecrosis in SLE patients who have already been diagnosed with symptomatic osteonecrosis. Additionally, we aimed to examine the relationship between proposed risk factors of osteonecrosis and the development of asymptomatic osteonecrosis.
View Article and Find Full Text PDFRole of hypercoagulability in multifocal osteonecrosis.
BMJ Case Rep
December 2024
Sports Injury Division, Department of Trauma Surgery, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India
Bone infarction describes bone marrow necrosis that occurs within a long bone's metaphysis or diaphysis. Multiple causative factors lead to ischaemia and subsequent necrosis of bone marrow. The role of hypercoagulability in bone ischaemia is a well-established phenomenon.
View Article and Find Full Text PDFMultifocal osteonecrosis due to the synergistic impact of inherited thrombophilia, autoimmunity and pregnancy: a case report.
Mod Rheumatol Case Rep
October 2024
Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Article Synopsis
- - Multifocal osteonecrosis is a rare condition that can cause significant bone weakness and fractures, highlighted in a case of a 34-year-old woman whose symptoms worsened during pregnancy.
- - Investigations revealed the patient had an undefined autoimmune condition and low Protein S levels, along with a novel genetic variant related to Protein S deficiency.
- - The combination of inherited thrombophilia, autoimmune issues, and pregnancy-related changes contributed to the patient's severe symptoms, with her genetic variant potentially explaining the link between autoimmunity and thrombophilia.
"Doughnut like appearance of femoral head" in multifocal osteonecrosis (MFON).
QJM
September 2024
Department of Nuclear Medicine, Army Hospital Research and Referral, New Delhi, India.
Systemic Sarcoidosis With Neurosarcoidosis Features as a Risk Factor for Multifocal Osteonecrosis.
Cureus
August 2024
Rheumatology, University of Maryland School of Medicine, Baltimore, USA.
Sarcoidosis is a systemic inflammatory disease that affects diverse organs such as the lungs, skin, eyes, and brain. Osseous involvement in sarcoidosis usually affects bones of the appendages with direct infiltration of non-caseating granulomas without bony infarcts. Symptoms of sarcoid bone lesions respond well to corticosteroid therapy.
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