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Nrf2 Activation as a Therapeutic Target for Flavonoids in Aging-Related Osteoporosis.
Nutrients
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College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.
Biological aging is a substantial change that leads to different diseases, including osteoporosis (OP), a condition involved in loss of bone density, deterioration of bone structure, and increased fracture risk. In old people, there is a natural decline in bone mineral density (BMD), exacerbated by hormonal changes, particularly during menopause, and it continues in the early postmenopausal years. During this transition time, hormonal alterations are linked to elevated oxidative stress (OS) and decreased antioxidant defenses, leading to a significant increase in OP.
View Article and Find Full Text PDFEffect of Hydride Types on the Fracture Behavior of a Novel Zirconium Alloy Under Different Hydrogen-Charging Current Densities.
Materials (Basel)
January 2025
State Key Laboratory of Explosion Science and Protection Technology, Beijing Institute of Technology, Beijing 100081, China.
Hydrogen embrittlement is a critical issue for zirconium alloys, which receives long-term attention in their applications. The formation of brittle hydrides facilitates crack initiation and propagation, thereby significantly reducing the material's ductility. This study investigates the tensile properties and hydride morphology of a novel zirconium alloy under different hydrogen-charging current densities ranging from 0 to 300 mA/cm, aiming to clarify the influence of hydrides on the fracture behavior of the alloy.
View Article and Find Full Text PDFInfluence of Microstructure on Music Properties of SWP-B Music Steel Wire Under Different Annealing Treatments.
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Joint R&D Center for Metallic Materials, Metallic Wire and Metallic Card Clothing, Xi'an 710021, China.
The mechanical properties of music wire are contingent upon its microstructure, which in turn influences its applications in music. Chinese stringed instruments necessitate exacting standards for comprehensive performance indexes, particularly with regard to the strength, resilience, and rigidity of the musical steel wires, which differ from the Western approach to musical wire. In this study, SWP-B music wire was selected for investigation through metal heat treatment, which was employed to regulate its microstructure characteristics.
View Article and Find Full Text PDFIn Situ EBSD Observation and Numerical Simulation of Microstructure Evolution and Strain Localization of DP780 Dual-Phase Steel.
Materials (Basel)
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School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China.
To reveal the microstructural evolution and stress-strain distribution of 780 MPa-grade ferrite/martensite dual-phase steel during a uniaxial tensile deformation process, the plastic deformation behavior under uniaxial tension was studied using in situ EBSD and crystal plastic finite element method (CPFEM). The results showed that the geometrically necessary dislocations (GND) in ferrite accumulated continuously, which is conducive to the formation of grain boundaries, but the texture distribution did not change significantly. The average misorientation angle decreased and the proportion of low-angle grain boundaries increased with the increase of strain.
View Article and Find Full Text PDFComparison of the Performance of Nonlinear Time-Dependent Constitutive Models Calibrated with Minimal Test Data Applied to an Epoxy Resin.
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January 2025
CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences, School of Science and Technology, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Epoxy resins are extensively employed as adhesives and matrices in fibre-reinforced composites. As polymers, they possess a viscoelastic nature and are prone to creep and stress relaxation even at room temperature. This phenomenon is also responsible for time-dependent failure or creep fracture due to cumulative strain.
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