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Fixation Methods, Complications, and Outcomes After Primary Fixation of Isolated Chondral Fragments in the Knee: A Systematic Review.
Am J Sports Med
January 2025
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Background: Knee injuries resulting in purely cartilaginous defects are rare, and controversy remains regarding the reliability of chondral-only fixation.
Purpose: To systematically review the literature for fixation methods and outcomes after primary fixation of chondral-only defects within the knee.
Study Design: Systematic review; Level of evidence, 5.
Tibial Spine Fractures.
Sports Med Arthrosc Rev
December 2024
Children's Healthcare of Atlanta, Atlanta, GA.
Tibial spine fractures (TSFs) are a relatively uncommon knee injury that most commonly occurs in skeletally immature pediatric patients following a sports or bicycle-related injury. Treatment of TSFs is guided based on fracture displacement on radiographs and associated injuries. Surgical treatment is recommended for displaced TSFs with arthroscopic or open reduction and fixation.
View Article and Find Full Text PDFHydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration-An Update on Preclinical Studies.
Bioengineering (Basel)
November 2024
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 450 Technology Drive, Rm 217, Pittsburgh, PA 15219, USA.
Autologous chondrocyte implantation (ACI) and matrix-induced ACI (MACI) have demonstrated improved clinical outcomes and reduced revision rates for treating osteochondral and chondral defects. However, their ability to achieve lasting, fully functional repair remains limited. To overcome these challenges, scaffold-enhanced ACI, particularly utilizing hydrogel-based biomaterials, has emerged as an innovative strategy.
View Article and Find Full Text PDFReturn to Activity After Patellofemoral Osteochondral Fracture: A Comparison of Metallic Screw and Bioabsorbable Fixation.
Orthop J Sports Med
November 2024
Division of Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Background: Patellofemoral osteochondral fractures (OCFs) have the potential to hinder patients' function and quality of life. Several fragment fixation techniques have been described, with both metallic screw and bioabsorbable fixation showing favorable functional outcomes. Despite the promising results associated with both fixation methods, no study has directly compared their functional outcomes.
View Article and Find Full Text PDFDifferentiated and Untreated Juvenile Chondrocyte Sheets Regenerate Cartilage Similarly .
Tissue Eng Part A
November 2024
Department of Molecular Pharmaceutics, Health Sciences, Cell Sheet Tissue Engineering Center (CSTEC), University of Utah, Salt Lake City, Utah, USA.
Osteoarthritis, a degenerative disease of articular cartilage and the leading cause of disability, is preceded by acute cartilage injury in a significant proportion of cases. Current auto- and allograft interventions are limited by supply and variability in therapeutic efficacy, prompting interest in tissue engineering solutions. Cell sheet tissue engineering, a scaffold-free regenerative technique, has shown promise in preclinical and clinical trials across various cell types and diseases.
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