Stachartone A (1), a novel phenylspirodrimane dimer, was isolated from cultures of the tin mine tailings-associated fungus Stachybotrys chartarum. Its structure was elucidated by means of spectroscopic methods. At the same time, compound (1) was tested for its cytotoxicity against five human cancer cell lines.
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http://dx.doi.org/10.1080/14786419.2017.1413565 | DOI Listing |
Front Fungal Biol
November 2024
Instititue of Food Chemistry, University of Münster, Münster, Germany.
J Biomol Struct Dyn
November 2024
Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, Bangladesh.
Phenylspirodrimanes (PSD) are the sesquiterpene quinone type meroterpenoids found in nature. PSDs are found to exhibit inhibitory activity against immunocomplex diseases, and tyrosine kinase receptors. Three of the different PSDs C1, C2, and C3 that have been reported to be isolated from the sponge-associated fungus MUT 3308 are selected for studying their possible inhibitory effect against type 2 diabetes mellitus.
View Article and Find Full Text PDFMolecules
December 2022
Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
Cannabinoid receptor ligands are renowned as being therapeutically crucial for treating diverse health disorders. Phenylspirodrimanes are meroterpenoids with unique and varied structural scaffolds, which are mainly reported from the genus and display an array of bioactivities. In this work, 114 phenylspirodrimanes reported from were screened for their CB2 agonistic potential using docking and molecular dynamic simulation studies.
View Article and Find Full Text PDFJ Fungi (Basel)
May 2022
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fungi are renowned as a fountainhead of bio-metabolites that could be employed for producing novel therapeutic agents, as well as enzymes with wide biotechnological and industrial applications. (black mold) (Stachybotriaceae) is a toxigenic fungus that is commonly found in damp environments. This fungus has the capacity to produce various classes of bio-metabolites with unrivaled structural features, including cyclosporins, cochlioquinones, atranones, trichothecenes, dolabellanes, phenylspirodrimanes, xanthones, and isoindoline and chromene derivatives.
View Article and Find Full Text PDFFront Microbiol
February 2021
Li Dak Sum Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China.
Mesophotic coral ecosystems (MCEs) have complex but understudied biodiversity, especially for natural products discovery. Untargeted metabolomics research on 80 extracts prepared from marine sponge-associated fungi, half from shallow reefs (<30 m) and half from MCEs (30-150 m), facilitated prioritization for further study a fungus from a 103 m deep sponge. LC-MS target-directed isolation yielded a series of new compounds, cymopolyphenols A-F (-), and two known phenylspirodrimanes, F1839-I () and stachybotrylactone ().
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