The plants in the genus Gardenia (Rubiaceae) have long been used as traditional medicines in China. In this study, two new 3,4-seco-cycloartane triterpenes, sootepin J (1) and sootepin K (2), and a novel nor-3,4-seco-cycloartane triterpenes, sootepin L (3), together with two known compounds (4-5), were isolated from the methanolic extract of the leaves and twigs of Gardenia sootepensis. The structures of the new compounds were elucidated by combinations of 1D, 2D NMR experiments and HR-MS data, while the known compounds were identified by comparison of the NMR data with previously published data.
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http://dx.doi.org/10.1080/14786419.2017.1413561 | DOI Listing |
Chem Biodivers
January 2025
Liverpool John Moores University, Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Diospyros discolor Willd., commonly known as Velvet apple or Mabolo, is an underutilized fruit. Traditionally, various parts of D.
View Article and Find Full Text PDFHeliyon
November 2024
Avian Nutrition and Feed Technology Division, Central Avian Research Institute, Izatnagar, 243 122, India.
The principal constituent of liquorice root () is glycyrrhizin, a triterpene saponin that is approximately many times sweeter than sucrose, the main active component. This study aimed to investigate the dietary liquorice root powder (LRP) on production performance, serum biochemical, gut health and carcass characteristics of Kadaknath (KN) birds as replacement of antibiotic growth promoter. Day-old Kadaknath chicks (n = 240) with uniform body weight were selected randomly and divided into six different treatments, each one with five replicates and eight birds per replicate, and raised in battery brooder cages for 15 weeks.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Pharmacy, the Affiliated Hospital, Southwest Medical University, Luzhou, People's Republic of China.
Betulinic acid (BA) is a natural compound obtained from plant extracts and is known for its diverse pharmacological effects, including anti-tumor, antibacterial, anti-inflammatory, antiviral, and anti-atherosclerotic properties. Its potential in anti-tumor therapy has garnered considerable attention, particularly for the treatment of breast, lung, and liver cancers. However, the clinical utility of BA is greatly hindered by its poor water solubility, low bioavailability, and off-target toxicity.
View Article and Find Full Text PDFSkinmed
January 2025
Baylor Scott & White University Hospital, Dallas, TX.
Filsuvez (birch triterpenes) topical gel received approval in 2023 for the treatment of epidermolysis bullosa (EB) in pediatric patients (aged ≥6 months) and adults. It promotes wound healing by modulating inflammation, encouraging new tissue formation, and maintaining the skin barrier. In a randomized, double-blind, controlled, parallel-group, phase III trial (EASE, NCT03068780), 223 patients were randomly assigned to two groups: the first group received treatment with birch triterpenes topical gel (study gel, n = 109), and the second group received treatment with vehicle gel (n = 114).
View Article and Find Full Text PDFSci Rep
January 2025
The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Chronic kidney disease (CKD) stands as a formidable global health challenge, often advancing to end-stage renal disease (ESRD) with devastating morbidity and mortality. At the central of this progression lies podocyte injury, a critical determinant of glomerular dysfunction. Compound K (CK), a bioactive metabolite derived from ginsenoside, has emerged as a compelling candidate for nephroprotective therapy.
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