AI Article Synopsis
- Wild rabbits in parts of Australia experience reduced mortality from rabbit haemorrhagic disease virus (RHDV) due to the presence of the non-pathogenic calicivirus RCV-A1.
- Laboratory studies indicated that prior infection with RCV-A1 helps rabbits tolerate future RHDV infections, leading to higher survival rates.
- Field analysis suggests that RCV-A1 infection may also lower the chances of getting RHDV, providing deeper insights into the interactions between these viruses beyond basic seroprevalence data.
Article Abstract
Mortality caused by rabbit haemorrhagic disease virus (RHDV) in wild rabbits is reduced in parts of Australia where the related, non-pathogenic calicivirus RCV-A1 is endemic. Laboratory experiments previously showed that prior infection with RCV-A1 enabled rabbits to better withstand subsequent infection with highly virulent RHDV, and this was assumed to explain higher survival. Here, we analyse serological data from the field suggesting that reduced mortality rates among wild rabbits may also result from rabbits previously infected with RCV-A1 having a reduced likelihood of RHDV infection. We discuss the possible mechanisms underlying this finding and its implications. The methods we describe for analysing field data gave far greater insights into epidemiological processes and virus interactions than gained from reporting basic seroprevalence rates alone.
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| http://dx.doi.org/10.1111/tbed.12786 | DOI Listing |
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