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Risk Factors for Digital Replantation Failure: A Nomogram Prediction Model.
Ther Clin Risk Manag
December 2024
Department of Hand Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People's Republic of China.
Article Synopsis
- The study aimed to investigate risk factors for digital necrosis (DN) following multiple digital replantation, highlighting its potential complications.
- Researchers analyzed patient data from Jan. 2017 to Jan. 2024, categorizing patients into two groups: those with DN (necrosis group) and those without (success group), using various statistical analyses including logistic regression.
- Findings indicated an 83.7% survival rate, identifying D-dimer and C-reactive protein (CRP) as independent risk factors for DN, leading to the creation of a nomogram prediction model for effective clinical use.
Successful Multimodal Treatment of Uterine Rhabdomyosarcoma.
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December 2024
Children's Hospital of Philadelphia, Division of Urology, Philadelphia, PA.
Uterine rhabdomyosarcoma is exceedingly rare. The treatment strategy has evolved from aggressive local control with upfront surgery followed by radiation to a more conservative approach with chemotherapy followed by additional treatment pending response, which is outlined in a recent consensus statement from the International Soft-Tissue Sarcoma Consortium. We present a case of a 2-year-old with intermediate risk uterine rhabdomyosarcoma.
View Article and Find Full Text PDFCombination of Adult Mesenchymal Stem Cell Therapy and Immunomodulation with Dimethyl Fumarate Following Spinal Cord Ventral Root Repair.
Biology (Basel)
November 2024
Laboratory of Nerve Regeneration, University of Campinas (UNICAMP), Campinas 13083-865, SP, Brazil.
Spinal cord injury results in significant motor and sensory loss. In the experimental ventral root avulsion (VRA) model, the ventral (motor) roots are disconnected from the spinal cord surface, disrupting contact between spinal motoneurons and muscle fibers. Axotomized motoneurons typically degenerate within two to three weeks after avulsion, the situation being exacerbated by an increased glial response and chronic inflammation.
View Article and Find Full Text PDFIschemia Time in Extremity Allotransplantation: A Comprehensive Review.
Hand (N Y)
November 2024
Harvard Medical School, Boston, MA, USA.
In response to the widespread occurrence of limb loss and the transformative potential of extremity vascularized composite allotransplantation (VCA), we examine the impact of warm and cold ischemia duration on limb survival and functional recovery. Our insights into warm ischemia are largely derived from relevant literature on replantation and revascularization. Studies indicate that achieving reperfusion within 5 to 6 hours of warm ischemia is critical for limb survival, and within 3 hours for curbing significant functional deficits.
View Article and Find Full Text PDFLevel of knowledge and attitude of spanish primary school teachers regarding tooth avulsion.
J Clin Exp Dent
October 2024
Department of Stomatology, Endodontic Section, School of Dentistry, University of Sevilla, Sevilla, Spain.
Background: Nowadays, traumatic dental injuries (TDIs) have a growing prevalence and incidence worldwide, reaching their highest numbers in school-age children. The management of dental avulsion requires an important challenge for the clinicians and the prognosis depends on an immediate and an appropriate emergency action. In this regard, primary school teachers are in a privileged position to assist injured children.
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