AI Article Synopsis
- A study conducted at Infectious Diseases & Beliaghata-General Hospital in Kolkata from May 2012 to April 2013 examined diarrheal disease in patients of different age groups, collecting stool samples from 830 children under 5 and 728 adults over 5 years old.* -
- Results showed a high prevalence of Group-A rotavirus (GARV) in children, with 53.4% testing positive, compared to only 6.04% in adults; the most common strains found were G2P[4] and G9P[4].* -
- The study suggested that female caregivers may be at a higher risk of infection, as 75% of rotavirus-positive cases were
Article Abstract
In hospital-based diarrhoeal disease surveillance at Infectious Diseases & Beliaghata-General Hospital (May-2012 to April-2013), Kolkata, India, stool samples were collected from patients < 5 years (n = 830) and > 5 years of age (n = 728) hospitalized with diarrhea. Group-A rotavirus (GARV) was identified by ELISA followed by multiplex RT-PCR. In children < 5 years of age, 53.4% of the samples were positive for GARV. In patients > 5 years to 90 years old, only 6.04% (n = 44) tested positive for GARV. G2P[4] strains (n = 16 [36.36%]) were the most prevalent, followed by G9P[4] strains (n = 13 [29.54%]), while P[4]-(n = 30 [68.18%]) was most prevalent among the P genotypes. The GARV strains G2, G9 and P[4] detected in adults clustered together in the phylogenetic tree with the GARV strains identified in children (< 5 years) during the same period. Rotavirus positivity was high among female patients (75%), suggesting that caregivers (mother/grandmother/older-siblings) may get infected through young children or may act as carriers for transmission.
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| http://dx.doi.org/10.1007/s00705-017-3670-0 | DOI Listing |
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