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This study aimed to evaluate the effect of ethyl acetate fraction (EAF) isolated from Molineria latifolia rhizome as dietary interventions for type 2 diabetes mellitus (T2DM) and its underlying molecular mechanisms in vivo. Experimental rats were induced by high fat diet feeding coupled with combined exposure to streptozotocin and nicotinamide. Treatment with EAF improved glucose tolerance and lipid profiles, but the insulin secretion was unaltered. Gene expression analyses on insulin/adipocytokine signalling-related genes demonstrated tissue-specific transcriptional responses. In skeletal muscle and liver tissues, Socs1, Tnf and Mapk8 showed consistent transcript regulation. Furthermore, hepatic translational analyses revealed sensitization on proximal insulin signalling, with reduced expression of IRS1 serine phosphorylation, increased IRS1 tyrosine phosphorylation and increased phospho-AKT (Ser473). The present findings suggested that EAF exerted its effect by modulating insulin signalling, potentially via IRS1/AKT activation. The pharmacological attributes of EAF may implicate its potential therapeutic applications for diabetes management.
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http://dx.doi.org/10.1016/j.biopha.2017.12.002 | DOI Listing |
Environ Sci Technol
December 2024
Beijing Key Laboratory for Green Catalysis and Separation, Key Laboratory of Beijing on Regional Air Pollution Control, Key Laboratory of Advanced Functional Materials, Education Ministry of China, Laboratory of Catalysis Chemistry and Nanoscience, Department of Chemical Engineering and Technology, College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.
Chlorinated and oxygenated volatile organic compounds (CVOCs and OVOCs) pose a significant threat to human health. Catalytic oxidation effectively removes these pollutants, but catalyst deactivation is a challenge. Our study focused on the hydrolysis oxidation of chlorobenzene (CB) and ethyl acetate (EA) over Ru/MO/HZSM-5 (M = W, Mo).
View Article and Find Full Text PDFObjective: Study of 2.6-di(propan-2-yl)phenol (2.6-di(P-2-yl)F) distribution nature in warm-blooded in case of fatal poisoning due to intragastric administration of the substance.
View Article and Find Full Text PDFChem Biodivers
December 2024
CSIR - North East Institute of Science and Technology, Centre for Pre-clinical Studies, Pulibor, 785006, Jorhat, INDIA.
This study highlights the prooxidant, antiproliferative and anti-inflammatory potential of ripe Meyna spinosa Roxb. ex Link fruit extracts. Chemical analysis by HRMS and AAS identified compounds like ursolic acid, oleanolic acid, lupeol, betulin, scopoletin, phloroglucinol, secoxyloganin, etc and micro-elements like iron, copper, zinc, and manganese.
View Article and Find Full Text PDFChem Biodivers
December 2024
Universidade Federal da Bahia, Química Orgânica, Rua Professor Sabino silva 356 Ed Saint Paul, ap 502, 40155250, Salvador, BRAZIL.
Blanchetia heterotricha is a species popularly used for its medicinal properties. However, few scientific records report the investigation of its chemical composition and biological activity. Herein, a metabolomics and multivariate statistical analysis approach was used to assess the chemical composition, antioxidant, and antimicrobial activity of B.
View Article and Find Full Text PDFACS Omega
December 2024
Laboratory of Bioactive Natural Products, Department of Biochemistry, Institute of Biological Science, Federal University of Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil.
is a plant widely cultivated for food and medicinal purposes. species have been reported as anti-inflammatory, antibacterial, anxiolytic, and antinephritic agents. This study aimed to evaluate the anti-inflammatory potential of the ethanolic extract (EE) from the aerial parts of and its most promising fraction in models of acute and chronic inflammation, including a psoriasis-like mouse model.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!