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Medications and cognitive decline in Alzheimer's disease: Cohort cluster analysis of 15,428 patients.
J Alzheimers Dis
January 2025
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Background: Medications for comorbid conditions may affect cognition in Alzheimer's disease (AD).
Objective: To explore the association between common medications and cognition, measured with the Mini-Mental State Examination.
Methods: Cohort study including persons with AD from the Swedish Registry for Cognitive/Dementia Disorders (SveDem).
Background: Patients with chronic kidney disease (CKD) have serum, bone, and vascular abnormalities presenting as chronic kidney disease-mineral bone disorder (CKD-MBD) syndrome. This study sought to identify the parameters with the greatest relative impact on progression of CKD-MBD abnormalities.
Materials And Methods: This prospective study measured 237 parameters including serum markers, clinical variables, dual-energy X-ray absorptiometry (DXA) measurements, vascular calcifications, and histomorphometric results from bone samples obtained at baseline and after 2 - 3 years.
The Impact of Atorvastatin Treatment on the Distribution of Low-Density Lipoprotein Subfractions and the Level of Vitamin D in Patients After Acute Myocardial Infarction: Preliminary Findings.
Int J Mol Sci
October 2024
Department of Heart Diseases, Postgraduate Medical School, Masovian Brodnowski Hospital, 8 Kondratowicza Str., 03-242 Warsaw, Poland.
Clinical trial results indicate that statin therapy aimed at normalising the lipid profile can prevent and reduce the risk of cardiovascular events. Both LDL and HDL consist of several subfractions, with only the smallest and densest subfractions being the most atherogenic. We examine the effect of Atorvastatin treatment not only on basic lipid profile parameters but also atherogenic lipoprotein subfractions and 25(OH)D levels in patients after the first acute myocardial infarction.
View Article and Find Full Text PDFThe associations between modifiable risk factors and constipation: a comprehensive mendelian randomization study.
BMC Gastroenterol
October 2024
Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, China.
Objective: Early identification of modifiable risk factors is crucial for the prevention of constipation. This study systematically investigated the relationship between genetically predicted modifiable risk factors and constipation.
Methods: The inverse variance weighting (IVW) method was employed as the primary analytical approach.
Structural characterization and hypolipidemic activity of a natural polysaccharide from Suaeda salsa L.
Int J Biol Macromol
November 2024
Research Institute for Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Jinan 250355, China; National Center of Technology Innovation for Comprehensive Utilization of Saline-Alkali Land, Dongying 257345, China. Electronic address:
Herein, the identification and analysis of a newly discovered hypolipidemic polysaccharide extracted from Suaeda salsa L., SS3-N1, is reported. The weight-average molecular weight (Mw), number-average molecular weight (Mn), and dispersity (Ð) of SS3-N1 were determined to be 45.
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