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Feasibility and Acceptability of Collecting Passive Smartphone Data for Potential Use in Digital Phenotyping Among Family Caregivers and Patients With Advanced Cancer.
JCO Clin Cancer Inform
January 2025
School of Nursing, University of Alabama at Birmingham, Birmingham, AL.
Purpose: Modeling passively collected smartphone sensor data (called digital phenotyping) has the potential to detect distress among family caregivers and patients with advanced cancer and could lead to novel clinical models of cancer care. The purpose of this study was to assess the feasibility and acceptability of collecting passive smartphone data from family caregivers and their care recipients with advanced cancer over 24 weeks.
Methods: This was an observational feasibility study.
Molecular basis of hemoglobin binding and heme removal in .
Proc Natl Acad Sci U S A
January 2025
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.
To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. causes the life-threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface-displayed receptor HbpA. Here, we show using X-ray crystallography, NMR, and in situ binding measurements that selectively captures iron-loaded hemoglobin by partially ensconcing the heme molecules of its α subunits.
View Article and Find Full Text PDFPassive accumulation of alkaloids in inconspicuously colored frogs refines the evolutionary paradigm of acquired chemical defenses.
Elife
December 2024
Department of Chemistry and Physics, Indiana State University, Terre Haute, United States.
Understanding the origins of novel, complex phenotypes is a major goal in evolutionary biology. Poison frogs of the family Dendrobatidae have evolved the novel ability to acquire alkaloids from their diet for chemical defense at least three times. However, taxon sampling for alkaloids has been biased towards colorful species, without similar attention paid to inconspicuous ones that are often assumed to be undefended.
View Article and Find Full Text PDFNumerical Simulation on Self-Propulsion Characteristics of Bionic Flexible Foil Considering Ground Wall Effect.
Biomimetics (Basel)
December 2024
College of Oceanography, Hohai University, Nanjing 210024, China.
In order to figure out the wall effect on the propulsive property of an auto-propelled foil, the commercial open-source code ANSYS Fluent was employed to numerically evaluate the fluid dynamics of flexible foil under various wall distances. A virtual model of NACA0015 foil undergoing travelling wavy motion was adopted, and the research object included 2D and 3D models. To capture the foil's moving boundary, the dynamic grid technique coupled with the overlapping grid was utilized to realize the foil's positive deformation and passive forward motion.
View Article and Find Full Text PDFCommunication needs and support for children and adolescents with complex communication needs requiring hospitalization in Hong Kong: an explorative study.
Int J Qual Stud Health Well-being
December 2025
Mitchell Institute, Victoria University, Melbourne, Australia.
Purpose: Children with complex communication needs face particular challenges during hospitalization. This study aimed to understand the situation for hospitalized Hong Kong Chinese children with complex communication needs.
Methods: Six group interviews were conducted with 23 participants, including nurses, doctors, adolescents with acquired brain injury, parents of children with acquired brain injury or cerebral palsy, and community-based therapists.
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