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Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database.
CNS Drugs
July 2018
Department of Epidemiology of Health Products, French National Agency for Medicines and Health Products Safety (ANSM), 143-147 Blvd Anatole France, 93285, Saint-Denis, France.
Background: Hepatotoxicity may be a concern when prescribing antidepressants. Nevertheless, this risk remains poorly understood for serotonin and noradrenaline reuptake inhibitors (SNRIs: venlafaxine, milnacipran, duloxetine) and 'other antidepressants' (mianserin, mirtazapine, tianeptine and agomelatine), particularly in comparison with selective serotonin reuptake inhibitors (SSRIs: fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine, escitalopram), which are by far the most commonly prescribed antidepressants.
Objective: We quantified the risk of serious liver injury associated with new use of SNRIs and 'other antidepressants' compared with SSRIs in real-life practice.
[Agomelatine in real-life condition: A safe context of prescription? Results of a one-year single-center evaluation].
Therapie
September 2018
Service pharmacie, établissement public de santé Alsace-Nord, 67170 Brumath, France.
The Daily Functionality in a Major Depressive Episode Cohort of Romanian Patients - a Non-Interventional Study.
Maedica (Bucur)
March 2015
Department of Psychiatry, "Alexandru Obregia" Hospital of Psychiatry, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Objectives: The aim of this non-interventional, investigator driven study was to assess the functionality of patients with major depression under treatment with agomelatine in real life clinical practice.
Material And Methods: The study was multicenter, non-interventional and evaluated the functionality of the adult patients with a DSM-IV diagnosis of MDD (single or recurrent episode and no treatment in the previous 6 months). It took place in Romania and it was a 10-weeks study.
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