Introduction: The aim of this study was to evaluate the effects of photodynamic therapy (PDT) on the bond strength and dentinal penetrability of cementation protocols using conventional resin cement (Relyx ARC; 3M ESPE, St Paul, MN) or self-adhesive (Relyx U200, 3M ESPE) after the glass fiber post cementation.
Methods: Forty human canine roots were endodontically treated and prepared for a fiber post. The roots were divided into 4 groups according to the cementation protocol and PDT use: conventional cement (CC), Relyx ARC; self-adhesive cement (SAC), Relyx U200 cement; PDT/CC, PDT + Relyx ARC; and PDT/SAC, PDT + Relyx U200. After cementation of the fiber posts, the roots were cross sectioned, and then specimens from the cervical, middle, and apical thirds of the prosthetic space were obtained. The specimens were submitted to the pushout test and dentinal penetration evaluation of the cementation protocol using laser confocal microscopy.
Results: PDT/CC presented the lowest bond strength to root dentin in the cervical third (P < .05). In the middle and apical thirds, all groups presented a similar bond strength (P > .05). PDT/CC presented the lowest dentinal penetration of the adhesive system in the cervical and apical thirds (P < .05).
Conclusions: PDT presented negative effects on the bond strength to dentin in the cervical third after cementation using Relyx ARC and on the dentinal penetrability of the etch-and-rinse adhesive system in the cervical and apical thirds of the prosthetic space.
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http://dx.doi.org/10.1016/j.joen.2017.08.035 | DOI Listing |
J Mater Chem B
January 2025
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang, China.
A pair of aza-BODIPY isomers, 1,7-di--butyl-3,5-dinaphthyl (Nap-BDP) and 1,7-dinaphthyl-3,5-di--butyl (revNap-BDP), were prepared in this study. According to the single crystal X-ray analysis, Nap-BDP exhibited an orthogonal structure. Owing to the difference in orthogonality and -Bu rotation between Nap-BDP and revNap-BDP, their spectral performances, including maximum absorption and emission, full width at half maximum, fluorescence quantum yield, photostability, singlet oxygen generation and photothermal conversion efficiency, were obviously different.
View Article and Find Full Text PDFAdv Mater
January 2025
Department of Chemistry, POSTECH-CATHOLIC Biomedical Engineering Institute, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Immunotherapy, particularly immune checkpoint blockade (ICB) therapies, has revolutionized oncology. However, it encounters challenges such as inadequate drug accumulation and limited efficacy against "cold" tumors characterized by lack of T cell infiltration and immunosuppressive microenvironments. Here, a controlled antibody production and releasing nanoparticle (CAPRN) is introduced, designed to augment ICB efficacy by facilitating tumor-targeted antibody production and inducing photodynamic cell death.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China.
Photodynamic therapy (PDT) holds great potential in cancer treatment, leveraging photosensitizers (PSs) to deliver targeted therapy. Fluorination can optimize the physicochemical and biological properties of PSs for better PDT performance. Here, we report some high-performance multifunctional PSs specifically designed for cancer PDT by fluorinating aza-BODIPY with perfluoro--butoxymethyl (PFBM) groups.
View Article and Find Full Text PDFTheranostics
January 2025
Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Malignant tumors have been a serious threat to human health with their increasing incidence. Difficulties with conventional treatments are toxicity, drug resistance, and recurrence. For this reason, non-invasive treatment modalities such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), and others have received much attention.
View Article and Find Full Text PDFSmall
January 2025
The Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Xingangzhong Road 466, Guangzhou, 518037, P. R. China.
The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences the generation of reactive oxygen species (ROS) and the photothermal conversion efficiency (PCE), posing a substantial hurdle to elevating the efficacy of photodynamic therapy (PDT) and photothermal therapy (PTT) for such NPs. In this article, three OPTAs by donor engineering are synthesized.
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