The genus Tragardhus Koch, 1956 (Pedinini: Melambiina) is revised to include nine Afrotropical species, five of which are new. A taxonomic treatment of the genus is provided including a morphological study, new species descriptions, keys, illustrations, and notes on species distributions. The following species are included: Tragardhus (Mitragardhus) nodosus Koch, 1956, T. (M.) ewae sp. nov., T. (M.) ryszardi sp. nov., T. (M.) zuzannae sp. nov., Tragardhus (Tragardhus) biapicalis Koch, 1956, T. (T.) glandipleurum Koch, 1956, T. (T.) jani sp. nov., T. (T.) majae sp. nov. and T. (T.) stigmaticus Koch, 1956. Additionally, a monotypic genus Pseudemmallus Koch, 1956, previously known from a single specimen representing P. aspericollis Koch, 1956, is redescribed based on newly available material.
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http://dx.doi.org/10.11646/zootaxa.4347.1.4 | DOI Listing |
This study presents a comprehensive survey of the extant diversity of harvestmen (Arachnida: Opiliones), a pivotal taxon for biogeography and conservation studies, across Earth's geopolitical entities (here treated as "countries"). The rationale for recognizing more than 200 of these countries lato sensu worldwide is provided. The four most diverse of these countries are here further subdivided in states/provinces resulting in over 300 controlled vocabulary terms (geographic areas that contain harvestman records).
View Article and Find Full Text PDFNat Protoc
October 2024
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Vaccines and immunotherapies that target peptide-major histocompatibility complexes (peptide-MHCs) have the potential to address multiple unmet medical needs in cancer and infectious disease. Designing vaccines and immunotherapies to target peptide-MHCs requires accurate identification of target peptides in infected or cancerous cells or tissue, and may require absolute or relative quantification to identify abundant targets and measure changes in presentation under different treatment conditions. Internal standard parallel reaction monitoring (also known as 'SureQuant') can be used to validate and/or quantify MHC peptides previously identified by using untargeted methods such as data-dependent acquisition.
View Article and Find Full Text PDFACS Nano
June 2024
Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.
In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple promising candidates in clinical trials. Regulatory agencies such as the Food and Drug Administration and the European Medicines Agency released important guidance documents facilitating nanoparticle-based drug product development, particularly in the context of liposomes and lipid-based carriers. Even with the progress achieved, it is clear that many barriers must still be overcome to accelerate translation into the clinic.
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May 2024
Royal Botanic Gardens, Kew, Richmond, UK.
Eur Heart J Digit Health
May 2023
Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Aims: One of the most important complications of heart transplantation is organ rejection, which is diagnosed on endomyocardial biopsies by pathologists. Computer-based systems could assist in the diagnostic process and potentially improve reproducibility. Here, we evaluated the feasibility of using deep learning in predicting the degree of cellular rejection from pathology slides as defined by the International Society for Heart and Lung Transplantation (ISHLT) grading system.
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