AI Article Synopsis
- This study focused on the levels of 60 angiogenic factors in the plasma of pregnant women whose fetuses had Down syndrome (trisomy 21), compared to a control group of women with healthy pregnancies.
- Researchers used a protein macroarray to measure these factors in blood samples from 20 women with Down syndrome pregnancies and 28 healthy controls.
- The results showed significant higher levels of five specific factors associated with inflammation and angiogenesis in the Down syndrome group, suggesting these factors might be involved in the development of the condition.
Article Abstract
Objective And Design: Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS).
Method: After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy newborns at term (i.e., 15-18 weeks of gestation). To assess the concentration of proteins in the blood plasma, we used a protein macroarray which enabled simultaneous determination of 60 angiogenic factors per sample.
Results: We observed a statistically significant increase in the concentration of these five angiogenic and inflammatory factors: TGFb1 (p = 0.039), angiostatin (p = 0.0142), I-309 (p = 0.0476), TGFb3 (p = 0.0395), and VEGF-D (p = 0.0173)-compared to concentrations in patients with healthy foetuses.
Conclusion: Our findings suggest that angiogenic factors may play role in DS pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731759 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189762 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!