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Effects of Simulated Microgravity In Vitro on Human Metaphase II Oocytes: An Electron Microscopy-Based Study.
Cells
May 2023
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University, 00165 Rome, Italy.
The Gravity Force to which living beings are subjected on Earth rules the functionality of most biological processes in many tissues. It has been reported that a situation of Microgravity (such as that occurring in space) causes negative effects on living beings. Astronauts returning from space shuttle missions or from the International Space Station have been diagnosed with various health problems, such as bone demineralization, muscle atrophy, cardiovascular deconditioning, and vestibular and sensory imbalance, including impaired visual acuity, altered metabolic and nutritional status, and immune system dysregulation.
View Article and Find Full Text PDFArticle Synopsis
- - Dyspnea is a type of respiratory discomfort often linked to heart or lung issues, but it can also stem from metabolic disorders.
- - The cause of dyspnea is complicated, arising from various brain interactions responding to internal sensations and pain.
- - When there's no obvious physical cause for dyspnea, known as dyspnea "sine materia," treatment focuses on behavioral therapy and breathing exercises, especially for those who are physically deconditioned.
Rehabilitation assisted by Space technology-A SAHC approach in immobilized patients-A case of stroke.
Front Physiol
January 2023
Greek Aerospace Medical Association and Space Research (GASMA-SR), Thessaloniki, Greece.
The idea behind the presentation of this case relates to utilizing space technology in earth applications with mutual benefit for both patients confined to bed and astronauts. Deconditioning and the progressiveness of skeletal muscle loss in the absence of adequate gravity stimulus have been of physiological concern. A robust countermeasure to muscle disuse is still a challenge for both immobilized patients and astronauts in long duration space missions.
View Article and Find Full Text PDFBone deconditioning during partial weight-bearing in rodents - A systematic review and meta-analysis.
Life Sci Space Res (Amst)
August 2022
Aerospace Medicine and Rehabilitation Laboratory, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, United Kingdom.
Space agencies are preparing to send humans to the Moon (16% Earth's gravity) and Mars (38% Earth's gravity), however, there is limited evidence regarding the effects of hypogravity on the skeletal system. A novel rodent partial weight-bearing (PWB) model may provide insight into how human bone responds to hypogravity. The aim of this study was to perform a systematic review investigating the effect of PWB on the structure and function of rodent bone.
View Article and Find Full Text PDFThe impact of COVID-19 lockdown on brain metabolism.
Hum Brain Mapp
February 2022
Service de Neurologie et de Neuropsychologie, Aix Marseille University, INSERM, Inst Neurosci Syst, & APHM, CHU Timone, Marseille, France.
This study aims to evaluate the impact of French national lockdown of 55 days on brain metabolism of patients with neurological disorders. Whole-brain voxel-based PET analysis was used to correlate F-FDG metabolism to the number of days after March 17, 2020 (in 95 patients; mean age: 54.3 years ± 15.
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