A phase I study was carried out on a new water-soluble nitrosourea, 6-deoxy-3,5 di-O-methyl 6-(3 methyl-3-nitrosoureido)-alpha-D-glucofuranoside (EDMN, CGP 6809), given every 2 weeks. A total of 18 patients received doses of 1, 2, 3, and 3.75 g/m2 as a 2- to 5-h infusion. Toxicity principally involved nausea and vomiting, hepatotoxicity, and abdominal pain. There was no evidence of cumulative toxicity. The dose of 3.75 g/m2 was not exceeded because in a previous phase I study, 4.5 g/m2 every 6 weeks was not tolerated; the recommended dose for phase II studies is 3.75 g/m2 every 2 weeks.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00451655 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of Cardiovascular Health of Children Ages 6 to 10 Years Conceived by Assisted Reproductive Technology.
JAMA Netw Open
November 2021
Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Importance: Assisted reproductive technology (ART) has been widely used for treatment of infertility and has brought millions of births worldwide. The health of offspring conceived by ART has been of much concern, and adverse cardiovascular health outcomes have been reported by previous studies.
Objective: To assess the cardiovascular health of children conceived by ART.
The relation of structural valve deterioration to adverse remodelling and outcome in patients with biological heart valve prostheses.
Eur Heart J Cardiovasc Imaging
January 2021
Department of Cardiology, OPEN-Odense Patient Data Explorative Network, Odense University Hospital and University of Southern Denmark, J. B. Winsløwsvej 4, DK-5000 Odense, Denmark.
Aims: Native valve aortic stenosis is associated with adverse remodelling of the left ventricle and remodelling is stopped or even reversed with aortic valve replacement (AVR). However, the degeneration of bioprostheses and development of structural valve deterioration (SVD) may affect this.
Methods And Results: To assess the association with SVD, remodelling and outcome 451 patients from a single surgical centre who had undergone AVR with a Mitroflow pericardial bioprosthesis were studied.
Immunochemotherapy using rituximab (RTX) and high-dose methotrexate (HD-MTX): an evaluation of the addition of RTX to HD-MTX in recurrent primary central nervous system lymphoma (PCNSL).
Jpn J Clin Oncol
October 2017
Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital.
Background: There is increasing evidence that MTX-based chemotherapy is superior to HD-MTX alone. Rituximab (RTX) is effective in a variety of B-cell lymphomas and may enter the brain. The purpose of this study is to evaluate the addition of RTX to HD-MTX in recurrent primary central nervous system lymphoma (PCNSL).
View Article and Find Full Text PDFMethotrexate-cytarabine-dexamethasone combination chemotherapy with or without rituximab in patients with primary central nervous system lymphoma.
Oncotarget
July 2017
Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Purpose: High-dose methotrexate based chemotherapy is the standard treatment for patients with newly diagnosed primary central nervous system lymphoma (PCNSL). The role of rituximab is controversial because of its large size, which limits its penetration of the blood-brain barrier. In this study, we investigated the efficacy and tolerability of adding rituximab to methotrexate-cytarabine-dexamethasone combination therapy (RMAD regimen).
View Article and Find Full Text PDFAssociation between Clinical and Doppler Echocardiographic Parameters with Sudden Death in Hemodialysis Patients.
Arq Bras Cardiol
August 2016
Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
Background: Sudden cardiac death (SCD) is the leading cause of death in maintenance hemodialysis (HD) patients, but there is little information about underlying risk factors.
Objectives: Evaluate the association between clinical and echocardiographic variables with SCD on HD patients.
Methods: Retrospective nested case-control study on chronic HD patients who were prospectively followed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!