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Unlabelled: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Clemastine fumarate, the over-the-counter antihistamine and muscarinic receptor blocker, has remyelinating potential in MS. A clemastine arm was added to an ongoing platform clinical trial TRAP-MS ( NCT03109288 ) to identify a cerebrospinal fluid (CSF) remyelination signature and to collect safety data on clemastine in patients progressing independently of relapse activity (PIRA).
View Article and Find Full Text PDFInfrared Video Imaging for the Identification and Quantification of Macula-Involving Symptomatic Vitreous Opacities.
J Vitreoretin Dis
January 2025
Texas Retina Center, Houston, TX, USA.
To evaluate whether infrared video imaging can supplement traditional examination and imaging methods to identify and quantify symptomatic vitreous opacities. A prospective nonrandomized nonmasked series was performed that included eyes of consecutive patients with a primary complaint of symptomatic vitreous opacities. A macular vitreous opacity score (0-4) was developed to grade the size of the opacities in relation to the macula after refixation of up, down, left, and right saccades.
View Article and Find Full Text PDFRevisiting Fat Graft Harvesting and Processing Technique to Optimize Its Regenerative Potential.
Plast Reconstr Surg Glob Open
January 2025
HayandraLab, Hayandra Peduli Foundation, Jakarta, Indonesia.
Background: The use of fat grafting has expanded to include cell and tissue regeneration, necessitating investigations to ensure the viability of stromal and adipose-derived mesenchymal stem cells (ASCs) within the transferred fat parcels. This study explored the impact of harvesting technique and centrifugation on the viability of stromal cells and ASCs in lipoaspirate.
Methods: Fat was harvested from patients undergoing fat grafting using 2 types of liposuction cannula: (A) a 3-mm blunt tip cannula with 3 smooth holes and (B) a 2.
Whole-body tumor segmentation from FDG-PET/CT: Leveraging a segmentation prior from tissue-wise projections.
Heliyon
January 2025
Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, SE-75185, Sweden.
: Accurate tumor detection and quantification are important for optimized therapy planning and evaluation. Total tumor burden is also an appealing biomarker for clinical trials. Manual examination and annotation of oncologic PET/CT is labor-intensive and demands a high level of expertise.
View Article and Find Full Text PDFHBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem Cells.
J Clin Transl Hepatol
January 2025
Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Background And Aims: Hepatitis B virus (HBV) infection contributes to hepatocellular carcinoma (HCC) tumorigenesis, drug resistance, and recurrence, although the underlying molecular mechanisms remain unclear. Recent studies suggest that HBV infection may be associated with liver cancer stem cells (LCSCs), but the exact mechanisms are yet to be resolved. In this study, we aimed to analyze the role of HBV infection in regulating the stemness of HCCs, which is closely linked to drug resistance.
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