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Loss of increases type I interferon signalling and reduces pancreatic tumour growth by enhancing immune cell infiltration.
Front Immunol
January 2025
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer, and despite low incidence rates, it remains the sixth leading cause of cancer related deaths worldwide. Immunotherapy, which aims to enhance the immune system's ability to recognize and eliminate cancer cells, has emerged as a promising approach in the battle against PDAC. PARP7, a mono-ADP-ribosyltransferase, is a negative regulator of the type I interferon (IFN-I) pathway and has been reported to reduce anti-tumour immunity.
View Article and Find Full Text PDFClinical trials in health-care metaverse - A conceptual overview.
Perspect Clin Res
August 2024
Department of Pharmacy Practice, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
Post-COVID-19, the emergence of newer technologies has taken center stage. One such technology is metaverse, which is an extension of existing technologies such as virtual reality (VR) and augmented reality (AR) that enables a fully immersive communication platform through the utilization of digital twins and avatars in a three-dimensional digital space. Literature review has shown that the adoption of such technologies in the field of clinical trials can help in improving the therapeutic outcomes in patients while having numerous other benefits.
View Article and Find Full Text PDFThe independent predictive value of admission serum ferritin concentration for prognosis in elderly patients with community-acquired pneumonia in the emergency department.
Front Cell Infect Microbiol
January 2025
Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Background: Community-acquired pneumonia (CAP) poses a significant health threat to the elderly population, leading to high morbidity and mortality rates. Serum ferritin, a critical indicator of iron metabolism, plays a pivotal role in inflammation and immune regulation. Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.
View Article and Find Full Text PDFGenomic analysis of the main epidemiological lineages of in Mexico.
Front Cell Infect Microbiol
January 2025
Centro de Investigación Sobre Enfermedades Infecciosas (CISEI), Departamento de Diagnóstico Epidemiológico, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Mexico.
has emerged as a critical global health threat due to its exceptional survival skills in adverse environment and its ability to acquire antibiotic resistance, presenting significant challenges for infection treatment and control. The World Health Organization has classified carbapenem-resistant as a "Critical Priority" pathogen to guide research and the development of control and prevention strategies. Epidemiological surveillance methodologies provide the tools necessary for classifying into international clonal lineages, facilitating the analysis of molecular characteristics, global dissemination, and evolution.
View Article and Find Full Text PDFCrafting the architecture of biomass-derived activated carbon electrochemical insights for supercapacitors: a review.
RSC Adv
January 2025
Plasmonic Nanomaterials Laboratory, Department of Nanoscience and Technology, PSG Institute of Advanced Studies Peelamedu Coimbatore-641 004 Tamilnadu India
Escalating energy demands have often ignited ground-breaking innovations in the current era of electrochemical energy storage systems. Supercapacitors (SCs) have emerged as frontrunners in this regard owing to their exclusive features such ultra-high cyclic stability, power density, and ability to be derived from sustainable sources. Despite their promising attributes, they typically fail in terms of energy density, which poses a significant hindrance to their widespread commercialization.
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