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APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.
Mol Neurodegener
January 2025
Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697-4545, USA.
Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer's Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects.
View Article and Find Full Text PDFA case of cardiac amyloidosis presenting stiff left atrial syndrome with severe calcification after first AF ablation.
J Cardiol Cases
January 2025
Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University, Kochi, Japan.
Unlabelled: Scarring of the left atrial (LA) wall from atrial ablation (AF) leads to the development of stiff LA syndrome. Multiple ablation treatments have been considered to be associated with the development of LA calcification (LAC). We report a case of wild-type transthyretin cardiac amyloidosis (CA) who presented with worsening heart failure due to stiff LA syndrome despite the condition after initial ablation for AF.
View Article and Find Full Text PDFMultimodality Imaging With Confocal Laser Endomicroscopy, Red Dichromatic Imaging, and Virtual Bronchoscopic Navigation Guided Recanalization of Complete Airway Obstruction Caused by Tracheobronchial Amyloidosis.
Arch Bronconeumol
January 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China. Electronic address:
Vitreous amyloidosis caused by Lys55Asn mutation in TTR with peripheral neuropathy onset: a case report of FAP-related complications.
Int J Ophthalmol
January 2025
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Left bundle branch area pacing in patients with transthyretin cardiac amyloidosis: a case series.
Eur Heart J Case Rep
January 2025
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
Background: Transthyretin cardiac amyloidosis is associated with various arrhythmias, including atrioventricular block. Despite this correlation, established treatments for transthyretin cardiac amyloidosis-associated arrhythmias are lacking. Left bundle branch area pacing is a promising physiological pacing technique.
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