AI Article Synopsis
- Orexin A is a neurotransmitter involved in regulating sleep and wakefulness, and recent studies indicate it may play a role in neurodevelopmental disorders like schizophrenia.
- The research conducted two experiments: one tested the effects of orexin A on the prepulse inhibition (PPI) response in non-sleep-deprived rats, finding that a specific dose (40μg/kg) reduced PPI%.
- The second experiment focused on sleep-deprived rats, showing that sleep deprivation impairs PPI% and that a lower dose of orexin A (10μg/kg) could fully restore PPI% at a specific intensity (78dB), highlighting a dose-dependent effect of orexin A on PPI response.
Article Abstract
Orexin is a novel neurotransmitter released from lateral hypothalamus, that is a crucial modulator in sleep/wakefulness system. Recent studies also suggest its possible role in the neurodevelopmental disorders, such as schizophrenia. Our study consists of two experiments, where we investigate the effect of orexin A (OXA), one of two isoforms of orexin that can pass blood brain barrier, on the prepulse inhibition of acoustic startle reflex. The first experiment tested the effect of OXA on PPI response of non-sleep-deprived rats via intraperitoneal injection 30min before testing. Our results show that 40μg/kg OXA attenuates PPI% at 78dB and 86dB prepulse intensities. The second experiment utilized 72-h REM sleep deprivation, as a model for sleep-deprivation-induced impairment of PPI response. Here, we tested the effect of OXA on PPI% of sleep-deprived rats via intraperitoneal injection at the last 30min of sleep deprivation, testing for PPI immediately afterwards. Our results showed that (1) sleep deprivation attenuates the PPI% at 74dB, 78dB and 86dB prepulse intensities and (2) 10μg/kg OXA completely restores the impaired PPI% at 78dB only, where the highest PPI% impairment was observed. These results suggest that orexin A modulates PPI response in rats in a dose-dependent manner, oppositely for non-sleep-deprived and sleep-deprived rats, and a more detailed investigation for the etiology of this effect should follow.
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| http://dx.doi.org/10.1016/j.bbr.2017.12.002 | DOI Listing |
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