AI Article Synopsis
- * Researchers developed a copper-infused 316L stainless steel stent (316L-Cu) that enhances the growth and spread of endothelial cells, improving their function compared to traditional 316L stents.
- * In animal tests, the 316L-Cu stent showed superior re-endothelialization properties and safety, indicating its potential as a new material for coronary stents.
Article Abstract
Drug eluting stents (DES) have been extensively applied nowadays and reduce the incidence of in-stent restenosis (ISR) greatly as compared with bare metal stents (BMS). However, the development of DES is hindered by the risk of late stent thrombosis (LST) due to delayed re-endothelialization, while endothelialization is an important process related to ISR and LST after implantation. 316L is a traditional stent material without bioactivity and have a high risk of ISR. Cu is recognized for angiogenesis stimulation in these years. Hence a copper bearing 316L stainless steel (316L-Cu) was prepared and evaluated about its effect on endothelialization in this paper. Compared with traditional 316L, it was proved that 316L-Cu increased the proliferation of co-cultured human umbilical vein endothelial cells (HUVECs) at first day. Moreover, HUVECs stretched better on the surface of 316L-Cu. It also improved the expression of angiogenesis related genes and tube formation ability in vitro. 316L-Cu-BMS, DES and 316L-BMS were implanted in swine to evaluate the re-endothelialization ability in vivo. And 316L-Cu-BMS showed the best effect on endothelialization with good biosafety. Consequently, 316L-Cu is a kind of promising BMS material for coronary field.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727161 | PMC |
| http://dx.doi.org/10.1038/s41598-017-17737-9 | DOI Listing |
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