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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727124 | PMC |
| http://dx.doi.org/10.1038/s41467-017-02135-6 | DOI Listing |
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- Ruxolitinib cream, shown to be safe and effective in a phase 3 study, has demonstrated its anti-inflammatory and itch-relieving properties in children aged 2-11 with mild to moderate atopic dermatitis (AD).
- The study focused on assessing safety, tolerability, pharmacokinetics, and quality of life while using the cream at maximum levels over longer periods, with 29 children participating and applying the cream twice daily for 4 weeks, followed by individualized usage.
- Results indicated that 31% of participants experienced treatment-related adverse events, but no severe health issues arose, and significant improvements in skin condition and quality of life were sustained for up to 52 weeks.
Gender and geographical bias in the editorial decision-making process of biomedical journals: a case-control study.
BMJ Evid Based Med
December 2024
BMJ Publishing Group, London, UK.
Objectives: To assess whether the gender (primary) and geographical affiliation (post-hoc) of the first and/or last authors are associated with publication decisions after peer review.
Design: Case-control study.
Setting: Biomedical journals.
Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes.
Diabetologia
December 2024
Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Progress in developing therapies for the maintenance of endogenous insulin secretion in, or the prevention of, type 1 diabetes has been hindered by limited animal models, the length and cost of clinical trials, difficulties in identifying individuals who will progress faster to a clinical diagnosis of type 1 diabetes, and heterogeneous clinical responses in intervention trials. Classic placebo-controlled intervention trials often include monotherapies, broad participant populations and extended follow-up periods focused on clinical endpoints. While this approach remains the 'gold standard' of clinical research, efforts are underway to implement new approaches harnessing the power of artificial intelligence and machine learning to accelerate drug discovery and efficacy testing.
View Article and Find Full Text PDFThe influence of mode of remote delivery on health-related quality of life outcome measures in British Sign Language: a mixed methods pilot randomised crossover trial.
Qual Life Res
December 2024
Grupo de Investigación Bienestar, Universidad de Las Américas, Quito, Ecuador.
Objectives: Little is known about the efficacy of remotely delivered outcome measures (psychological/health-related assessments) in a signed language for Deaf people. The objective is to explore the equivalence of two modes of remote delivery of health-related quality of life outcome measures in British Sign Language (BSL): asynchronous online assessment versus synchronous live face-to-face online assessment in sign language.
Methods: Thirty-one participants were recruited through Deaf networks and sign language media.
DE-PASS Best Evidence Statement (BESt): A Systematic Review and Meta-analysis on the Effectiveness of Trials on Device-Measured Physical Activity and Sedentary Behaviour and Their Determinants in Children Aged 5-12 Years.
Sports Med
December 2024
Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle Upon Tyne, UK.
Background: To combat the high prevalence of physical inactivity among children, there is an urgent need to develop and implement real-world interventions and policies that promote physical activity (PA) and reduce sedentary behaviour (SB). To inform policy makers, the current body of evidence for children's PA/SB interventions needs to be translated.
Objectives: The current systematic review and meta-analysis aimed to identify modifiable determinants of device-measured PA and SB targeted in available intervention studies with randomized controlled trial (RCT) and controlled trial (CT) designs in children and early adolescents (5-12 years) and to quantify the effects of the interventions within their respective settings on the determinants of PA/SB and the outcomes PA and SB.
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