AI Article Synopsis
- The study focused on the role of chemical stabilizers in enhancing the stability of live attenuated mumps vaccines.
- Three different formulations of mumps vaccines were tested on Guinea pigs to compare their ability to induce antibody production.
- Results showed that vaccines containing trehalose dihydrate and human serum albumin produced higher antibody levels compared to the standard formulation, indicating that certain stabilizers can improve vaccine effectiveness.
Article Abstract
Background: Chemical stabilizers are added to live attenuated vaccines for enhancing the virus stability. The aim of this study was to evaluate the effect of various stabilizers on preserving immunogenicity of lyophilized mumps vaccines.
Study Design: An experimental study.
Methods: Three mumps vaccines with different formulations were inoculated to three groups of Guinea pigs. Sterile water was injected to eight Guinea pigs as a control group. Blood samples were collected before inoculation and on 14, 28 and 42 d after vaccine injection. Mumps antibodies in the sera were measured using hemagglutination inhibition assay (HAI).
Results: All three formulated mumps vaccines induced antibody in Guinea pigs after two weeks. Formulation 1 containing trehalose dihydrate and formulation 2 comprised human serum albumin stimulated antibodies in the higher level than Razi routine formulation.
Conclusions: Various stabilizers have different preservation potencies that differently affect immune response against virus. More stable and more immunogenic vaccines can be produced using stabilizers containing trehalose dihydrate.
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