In order to discover novel eco-friendly lead compounds for plant pathogenic fungi control, a series of benzaldehyde thiosemicarbazide derivatives with a piperidine moiety have been designed and synthesized. Fungicidal activities of all the synthesized compounds were evaluated in vitro. The results indicated that all the title compounds exhibited moderate to good fungicidal activities. Compound displayed excellent activities against , , , and , with EC values lower than 10 μg/mL. Especially, in the case of , its activity (EC = 1.6 μg/mL) is superior to the commercial azoxystrobin (EC = 16.9 μg/mL) and close to fluopicolide (EC = 1.0 μg/mL). Initial structure-activity relationship (SAR) analysis showed that the heterocyclic piperidine group can influence the biological activities of the title compounds significantly. The fungicidal activity of compounds with piperidine is better than that of compounds without piperidine. The highly-active compound , with its simple structure and easy synthetic route, is worthy to be further studied as a new lead fungicide.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149837PMC
http://dx.doi.org/10.3390/molecules22122085DOI Listing

Publication Analysis

Top Keywords

fungicidal activity
8
thiosemicarbazide derivatives
8
derivatives piperidine
8
fungicidal activities
8
title compounds
8
compounds piperidine
8
compounds
6
piperidine
5
design synthesis
4
fungicidal
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!