AI Article Synopsis
- This review focuses on new focal therapy treatments for prostate cancer and highlights the rise of mpMRI-guided biopsies, which have led to increased image-guided treatments.
- Recent therapies under evaluation include partial prostatectomy, focal laser ablation, irreversible electroporation, vascular targeted photodynamic therapy, and focal radiofrequency ablation, detailed through recent phase 1 and 2 trial findings.
- Overall, while these treatments show promise with tolerable side effects, the short-term effectiveness is inconsistent, and long-term results are still needed to fully assess their impact.
Article Abstract
Purpose Of Review: Examine and discuss novel focal therapy treatment options for prostate cancer.
Recent Findings: With the widespread adoption of mpMRI-guided biopsies for prostate cancer, use of image-guided treatment of prostate cancer has increased. Focal therapies leading to partial gland ablation such as partial prostatectomy, focal laser ablation, irreversible electroporation, vascular targeted photodynamic therapy, and focal radiofrequency ablation have emerged and begun to be properly evaluated. This review covers published phase 1 and 2 trials of each treatment and discusses potential limitations of each modality.
Summary: Focal therapy of prostate cancer is being actively investigated. On the basis of limited published data, the treatments appear to be well tolerated and have an acceptable side effect profile. Importantly, short-term oncologic control has been mixed and there are no long-term outcomes. The acquisition of more data is essential to evaluate these novel technology platforms.
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| http://dx.doi.org/10.1097/MOU.0000000000000469 | DOI Listing |
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