Ru polyazaaromatic complexes have been studied with the aim of developing molecular tools for DNA and oligonucleotides. In this context, Ru-TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes have been developed as specific photoreagents targeting the genetic material. The advantage of such compounds is due to the formation of photo-addition products between the Ru-TAP complex and the biomolecule, originating from a photo-induced electron transfer process that takes place between the excited Ru-TAP complex and guanine (G) bases of DNA. This photo-addition has been more recently extended to amino acids in view of applications involving peptides, such as inhibition or photocontrol of proteins. More particularly, tryptophan (Trp) and Trp-containing peptides are also able to be photo-oxidized by Ru-TAP complexes, leading to the formation of photo-addition products. This mini review focuses on recent advances in the search for Ru polyazaaromatic photo-oxidizing complexes of interest as molecular tools and photoreagents for Trp-containing peptides and proteins. Different possible future directions in this field are also discussed.
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Perspectives of ruthenium(ii) polyazaaromatic photo-oxidizing complexes photoreactive towards tryptophan-containing peptides and derivatives.
Chem Commun (Camb)
January 2018
Organic Chemistry and Photochemistry, Université Libre de Bruxelles, (U. L. B.), 50 Av. F. D. Roosevelt, CP 160/08, 1050 Bruxelles, Belgium.
Ru polyazaaromatic complexes have been studied with the aim of developing molecular tools for DNA and oligonucleotides. In this context, Ru-TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes have been developed as specific photoreagents targeting the genetic material. The advantage of such compounds is due to the formation of photo-addition products between the Ru-TAP complex and the biomolecule, originating from a photo-induced electron transfer process that takes place between the excited Ru-TAP complex and guanine (G) bases of DNA.
View Article and Find Full Text PDFPhotochemistry of ruthenium(ii) complexes based on 1,4,5,8-tetraazaphenanthrene and 2,2'-bipyrazine: a comprehensive experimental and theoretical study.
Dalton Trans
May 2017
Organic Chemistry and Photochemistry, Université Libre de Bruxelles, (U. L. B.), 50 Av. F. D. Roosevelt, CP 160/08 1050, Bruxelles, Belgium.
Polyazaaromatic ruthenium(ii) complexes have been largely studied over the last decades, particularly in the scope of the biological applications, for the development of new diagnostic and phototherapeutic agents. In this context, Ru(ii) complexes able to react with biomolecules upon excitation are of great interest. Photo-oxidizing Ru(ii) complexes based on π-deficient ligands, such as bpz (2,2'-bypyrazine) and TAP (1,4,5,8-tetraazaphenathrene), were designed to allow a photo-induced electron transfer (PET) to take place in presence of biomolecules, thanks to their highly photo-oxidizing MLCT state.
View Article and Find Full Text PDFParameters influencing the photo-induced electron transfer from tryptophan-containing peptides to a Ru(II) complex: a systematic study.
Faraday Discuss
August 2016
Laboratoire de Chimie Organique et Photochimie CP160/08, Université libre de Bruxelles, 50 Av. Franklin D. Roosevelt, 1050 Brussels, Belgium.
Ruthenium(II) polyazaaromatic complexes have gained interest in recent decades as biomolecular tools, especially in the development of new phototherapeutic agents. These light emissive Ru complexes based on π-deficient ligands were first designed to allow a photo-induced electron transfer (PET) with the guanine base in DNA since their (3)MLCT state is highly photo-oxidizing. Later the field of research was extended to proteins with the highlighting of a PET process with the tryptophan residue.
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Curr Top Med Chem
July 2012
Université Libre de Bruxelles, Chimie Organique et Photochimie, CP 160/08, av. F.D. Roosevelt, 1050 Bruxelles, Belgium.
Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for Ru(II) polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of Ru(II) polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing Ru(II) complexes with nucleic acids.
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