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Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. | LitMetric

AI Article Synopsis

  • Resveratrol, a natural compound with potential health benefits, is metabolized in the body, leading to the formation of various products, including glucuronides and sulfates.
  • An analysis of mice shows that resveratrol and its metabolites are concentrated in the gastrointestinal organs, urine, and feces, but levels are lower in the liver and kidneys.
  • The study indicates that the expression of specific enzyme genes correlates with the metabolism of resveratrol, suggesting that similar metabolic patterns might occur in humans after consuming resveratrol-rich foods.

Article Abstract

Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the metabolism and tissue distribution of resveratrol in mice and assessed its association with the expression of UDP-glucuronosyltransferase (Ugt) and sulfotransferase (Sult) genes. Plasma, urine, feces, and various organs were analyzed using high-performance liquid chromatography at up to 8 h after intragastric resveratrol administration. The metabolism of resveratrol was pronounced, leading to the formation of resveratrol glucuronides and sulfates. Concentrations of resveratrol and its metabolites were high in the gastrointestinal organs, urine, and feces, but low in the liver and kidneys. In lung, heart, thymus, and brain tissues, parent resveratrol levels exceeded the sulfate and glucuronide concentrations. The formation of resveratrol conjugates correlated with the expression of certain and genes. Reverse transcription quantitative PCR (RT-qPCR) analysis revealed high mRNA expression of in the liver, duodenum, jejunum, ileum, and colon, leading to high concentrations of resveratrol-3-O-glucuronide in these organs. Strong correlations of resveratrol-3-O-sulfate and resveratrol-3-O-4'-O-disulfate formation with mRNA expression were also observed, particularly in the liver and colon. In summary, our data revealed organ-specific expression of in mice that strongly affects resveratrol concentrations; this may also be predictive in humans following oral uptake of dietary resveratrol.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748797PMC
http://dx.doi.org/10.3390/nu9121347DOI Listing

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