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Inhibition of the polyol pathway by extract: plausible implications for diabetic retinopathy treatment.
Front Pharmacol
December 2024
Department of Biosciences, Integral University, Lucknow, India.
Introduction: Diabetic retinopathy is a significant microvascular disorder and the leading cause of vision impairment in working-age individuals. Hyperglycemia triggers retinal damage through mechanisms such as the polyol pathway and the accumulation of advanced glycation end products (AGEs). Inhibiting key enzymes in this pathway, aldose reductase (AR) and sorbitol dehydrogenase (SD), alongside preventing AGE formation, may offer therapeutic strategies for diabetic retinopathy and other vascular complications.
View Article and Find Full Text PDFTrends and projections of type 2 diabetes mellitus in South Asia: a three-decade analysis and forecast through 2031 using global burden of disease study (1990 - 2021).
Expert Rev Endocrinol Metab
January 2025
Faculty of Medicine, University of Cyberjaya, Cyberjaya, Malaysia.
Background: The rapid rise of non-communicable diseases, particularly type 2 diabetes mellitus (T2DM), poses a significant global public health challenge, with South Asia experiencing an increasingly severe burden. This study aimed to analyse historical trends of T2DM across South Asia from 1990 to 2021 and forecast incidence through 2031.
Research Design And Methods: We carried out analysis based on the data from the 2021 Global burden of disease study.
Predictive Factors of Dental Implant Failure: A Retrospective Study Using Decision Tree Regression.
Cureus
December 2024
Department of Orthodontics, Kothiwal Dental College and Research Centre, Moradabad, IND.
Introduction: Dental implants are routinely used to replace missing teeth. Therefore, the primary aim of the present study was to assess the single-unit implant failure rate over a period of seven years from 2015 to 2021, with a minimum of two years post-implant follow-up. The secondary aim was to identify the risk factors associated with implant failure using machine learning decision tree regression and Kaplan-Meier survival analyses.
View Article and Find Full Text PDFUnderstanding Dental Clinical Trainees' Knowledge and Attitudes Toward Managing Diabetic Patients: Insights From a University Dental Training Center.
Cureus
December 2024
Microbiology, Viswabharathi Medical College and General Hospital, Kurnool, IND.
Background: Dental patients with diabetes require comprehensive care to maintain their metabolic stability during dental treatments. Clinicians' understanding of diabetes symptoms and management strategies is essential for minimizing risks associated with dental procedures, especially since undiagnosed diabetic patients may also seek dental care. This study aimed to assess dental clinical trainees' knowledge and attitudes toward managing diabetic patients.
View Article and Find Full Text PDFEffect of Dental Follow-Up on Dental Consultation and Checkup Rates for Patients With Diabetes: A Multicenter Before-After Study.
Cureus
December 2024
Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, JPN.
Background Patients with diabetes have an increased risk of developing periodontal diseases. Periodontal treatment also improves glycemic control. Therefore, regular dental consultations and checkups are important.
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